<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3019</journal-id>
<journal-title><![CDATA[MEDISAN]]></journal-title>
<abbrev-journal-title><![CDATA[MEDISAN]]></abbrev-journal-title>
<issn>1029-3019</issn>
<publisher>
<publisher-name><![CDATA[Centro Provincial de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30192022000500005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Eritrocitos humanos como biomodelo farmacológico de citoprotección antioxidante para la evaluación de nuevas alternativas terapéuticas en pacientes con COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Human erythrocytes as pharmacological biomodel of antioxidant cytoprotection for the evaluation of new therapeutic alternatives in patients with COVID-19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mora Tassé]]></surname>
<given-names><![CDATA[Yoandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fong Lores]]></surname>
<given-names><![CDATA[Onel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Berenguer Rivas]]></surname>
<given-names><![CDATA[Clara Azalea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Andrés]]></surname>
<given-names><![CDATA[Irela Yolaidys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas Centro de Toxicología y Biomedicina ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Oriente Facultad de Ciencias Naturales y Exactas Departamento de Farmacia]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2022</year>
</pub-date>
<volume>26</volume>
<numero>5</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30192022000500005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30192022000500005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30192022000500005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El estrés oxidativo puede afectar las membranas biológicas de diferentes tipos celulares en el organismo, lo cual se ha evidenciado en los daños a los tejidos y órganos de pacientes con COVID-19, por lo cual las investigaciones recientes están relacionadas con la búsqueda de fármacos citoprotectores y antioxidantes que minimicen estos daños.  Objetivo:  Evaluar los eritrocitos humanos como biomodelo farmacológico de citoprotección antioxidante.  Métodos:  Se evaluó el modelo de citotoxicidad en eritrocitos inducido por peróxido de hidrógeno y se valoró el sistema de diagnóstico propuesto en un ensayo de citoprotección en eritrocitos, con el empleo del ácido ascórbico como sustancia de referencia.  Resultados:  Para la concentración de eritrocitos utilizada se logró un modelo de citotoxicidad a la concentración de 10 mM de peróxido a los 30 minutos de incubación. La sustancia de referencia empleada no mostró signos de citotoxicidad en el test de hemólisis. En el ensayo de citoprotección se evidenció un efecto farmacológico del referente, con un valor del índice de citoprotección de 12,71 µg/mL. El estudio de microscopía óptica mostró daños morfológicos severos en los eritrocitos tratados con peróxido de tipo esferocitos, equinocitos y esferoequinocitos, que disminuyeron significativamente en presencia de dicha sustancia de referencia.  Conclusiones:  El biomodelo farmacológico propuesto puede ser empleado en la evaluación de nuevas alternativas terapéuticas con propiedades citoprotectoras antioxidantes para el tratamiento de pacientes con COVID-19.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The oxidative stress can affect the biological membranes of different cellular types in the organism, which has been evidenced in the damages to the tissues and organs of patients with COVID-19, reason why the recent investigations are related to the search of cytoprotector and antioxidant drugs that minimize these damages.  Objective:  To evaluate the human erythrocytes as pharmacological biomodel of antioxidant cytoprotection.  Methods:  The cytotoxicity pattern was evaluated in erythrocytes induced by peroxide of hydrogen and the system of diagnosis proposed was valued in a cytoprotection assay in erythrocytes, with the use of ascorbic acid as reference substance.  Results: For the concentration of erythrocytes used a cytotoxicity model was achieved to the concentration of 10 mM of peroxide at 30 minutes of incubation. The substance of reference used didn't show cytotoxicity signs in the hemolysis test. In the cytoprotection assay a pharmacological effect of the referent was evidenced, with a value of the cytoprotection index of 12.71 µg/mL. The study of optic microscopy showed severe morphological damages in the erythrocytes treated with peroxide of spherocytes, echinocytes and spheroechinocytes type that significantly diminished in presence of this reference substance.  Conclusions:  The proposed pharmacological biomodel can be used in the evaluation of new therapeutic alternatives with antioxidant cytoprotector properties for the treatment of patients with COVID-19.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[biomodelo farmacológico]]></kwd>
<kwd lng="es"><![CDATA[citoprotección]]></kwd>
<kwd lng="es"><![CDATA[antioxidantes]]></kwd>
<kwd lng="es"><![CDATA[eritrocitos humanos]]></kwd>
<kwd lng="en"><![CDATA[pharmacological biomodel]]></kwd>
<kwd lng="en"><![CDATA[cytoprotection]]></kwd>
<kwd lng="en"><![CDATA[antioxidant]]></kwd>
<kwd lng="en"><![CDATA[human erythrocytes]]></kwd>
</kwd-group>
</article-meta>
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