<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942021000500007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cambios histopatológicos de la mucosa traqueal en pacientes con intubación endotraqueal]]></article-title>
<article-title xml:lang="en"><![CDATA[Histopathological changes of the tracheal mucosa in patients with endotracheal intubation]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez Marín]]></surname>
<given-names><![CDATA[Yaíma de la Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fuentes Díaz]]></surname>
<given-names><![CDATA[Zaily]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Llanes Mesa]]></surname>
<given-names><![CDATA[Llanetsy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Salazar]]></surname>
<given-names><![CDATA[Orlando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuenca Álvarez]]></surname>
<given-names><![CDATA[Solange María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey  ]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey Hospital Oncológico Provincial Docente &#8220;María Curie&#8221; ]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey Hospital Universitario &#8220;Manuel Ascunce Domenech&#8221; ]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<volume>25</volume>
<numero>5</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942021000500007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942021000500007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942021000500007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  el daño causado por la exposición al tubo endotraqueal se asocia a una respuesta inflamatoria aguda en los tejidos, en la que participan mecanismos de respuesta inmune innata.  Objetivo:  caracterizar los cambios histopatológicos de la mucosa traqueal en pacientes con intubación endotraqueal.  Métodos:  se realizó un estudio observacional, descriptivo y transversal en pacientes fallecidos atendidos en el Hospital Universitario &#8220;Manuel Ascunce Domenech&#8221;, en el período mayo de 2018 - enero de 2020 que requirieron intubación endotraqueal. El epitelio traqueal se estudió mediante la necropsia, se realizó examen macroscópico y microscópico de la tráquea.  Resultados:  La congestión constituyó el principal cambio histopatológico del epitelio de la mucosa traqueal (100 %) y la inflamación aguda el de la lámina propia (100 %). Se encontró predominio de pacientes entre 60 y 79 años (44,4 %), con mayor presencia de congestión y ulceración (44,5 % y 46,1 % respectivamente). Se encontró predominio de paciente del sexo masculino (55,6 %), con mayor presencia de congestión y ulceración (55,6 % y 61,5 % respectivamente). Se encontró una relación estadística significativa entre cambios histopatológicos y tiempo de intubación (p&lt;0,01) y entre cambios de la lámina propia y tiempo de intubación (p&lt;0,01).  Conclusiones:  en los pacientes intubados, principalmente del sexo masculino y pasada la sexta década de vida, fue frecuente la presencia de congestión del epitelio de la mucosa y de inflamación aguda de la lámina propia. Los cambios histopatológicos y los cambios de la lámina propia se encontraron relacionados al tiempo de intubación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  damage caused by exposure to the endotracheal tube is associated with an acute inflammatory response in tissues, involving innate immune response mechanisms.  Objective: to characterize the histopathological changes of the tracheal mucosa in patients with endotracheal intubation.  Methods:  an observational, descriptive and cross-sectional study was conducted in deceased patients attended at Manuel Ascunce Domenech University Hospital in the period May 2018 - January 2020 who required endotracheal intubation. The tracheal epithelium was studied by necropsy, macroscopic and microscopic examination of the trachea was performed.  Results:  congestion was the main histopathological change of the tracheal mucosal epithelium (100 %) and acute inflammation that of the lamina propria (100 %). There was a predominance of patients between 60 and 79 years old (44,4 %), with greater presence of congestion and ulceration (44,5 % and 46,1 % respectively). There was a predominance of male patients (55,6 %), with greater presence of congestion and ulceration (55,6 % and 61,5 % respectively). A significant statistical relationship was found between histopathological changes and intubation time (p&lt;0,01) and between lamina propria changes and intubation time (p&lt;0,01).  Conclusions:  in intubated patients, mainly male and past the sixth decade of life, the presence of congestion of the mucosal epithelium and acute inflammation of the lamina propria was frequent. Histopathological changes and changes in the lamina propria were found to be related to intubation time.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[INTUBACIÓN ENDOTRAQUEAL]]></kwd>
<kwd lng="es"><![CDATA[MUCOSA]]></kwd>
<kwd lng="es"><![CDATA[HISTOLOGÍA]]></kwd>
<kwd lng="es"><![CDATA[INFLAMACIÓN]]></kwd>
<kwd lng="en"><![CDATA[INTUBATION, INTRATRACHEAL]]></kwd>
<kwd lng="en"><![CDATA[MUCOSAL]]></kwd>
<kwd lng="en"><![CDATA[HISTOLOGY]]></kwd>
<kwd lng="en"><![CDATA[INFLAMMATION]]></kwd>
</kwd-group>
</article-meta>
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