<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942022000200017</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Errores innatos de la inmunidad en pacientes oncohematológicos pediátricos de Pinar del Río]]></article-title>
<article-title xml:lang="en"><![CDATA[Inborn errors of immunity in pediatric oncohematological patients from Pinar del Río]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miló-Valdés]]></surname>
<given-names><![CDATA[Carlos Alfredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orraca-Castillo]]></surname>
<given-names><![CDATA[Odalys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdés-Acosta]]></surname>
<given-names><![CDATA[Madelayne]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barreras-Sixto]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdés-Soho]]></surname>
<given-names><![CDATA[Cesar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-González]]></surname>
<given-names><![CDATA[Jorge Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Hospital Pediátrico Provincial Docente &#8220;Pepe Portilla&#8221; ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Facultad de Ciencias Médicas &#8220;Dr. Ernesto Che Guevara de la Serna&#8221; ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>26</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942022000200017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942022000200017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942022000200017&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la susceptibilidad incrementada a procesos infecciosos se considera el principal signo de sugestivo de inmunodeficiencia; sin embargo, otras manifestaciones como las de índole hematológico y/u oncológico pueden ser parte de la evolución e incluso del debut de un error innato de la inmunidad.  Objetivo:  identificar los pacientes con diagnóstico probable de errores innatos de la inmunidad en el servicio de oncohematología pediátrica del Hospital Pediátrico &#8220;Pepe Portilla&#8221; de Pinar del Río, en el período de enero de 1979 hasta marzo de 2021.  Métodos:  se realizó un estudio observacional, descriptivo de corte transversal donde la muestra estuvo constituida por 103 pacientes. Se estudiaron las variables: enfermedad oncohematológica diagnosticada, diagnóstico probable de error innato de la inmunidad y signos de alarma de inmunodeficiencia primaria.  Resultados:  el 87,4 % presentó diagnóstico de alguna enfermedad oncológica. Se hallaron cinco pacientes con diagnóstico probable de un error innato de la inmunidad (anemia de Fanconi y aplasia medular). El 54,5 % de los pacientes no leucémicos y solo el 24,1 % de los leucémicos tuvieron al menos uno y hasta tres signos de alarma para inmunodeficiencia.  Conclusiones:  los signos de alarma de la Fundación Jeffrey Modell para el diagnóstico de inmunodeficiencias primarias no resultaron útiles en los pacientes con hematopatías, por lo que se pudieran implementar otros criterios para la identificación de estos trastornos. Se impone una reevaluación de estos pacientes por el grupo provincial de inmunología con vistas al diagnóstico de errores innatos de la inmunidad y su tratamiento integral.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  increased susceptibility to infectious processes is considered the main sign suggestive of immunodeficiency; however, other manifestations such as those of hematological and/or oncological nature may be part of the evolution and even the onset of an inborn error of immunity.  Objective:  to identify patients with probable diagnosis of inborn errors of immunity in the pediatric oncohematology service at Pepe Portilla Pediatric Provincial Teaching Hospital in Pinar del Rio during the period from January 1979 to March 2021.  Methods:  an observational, descriptive, cross-sectional study was carried out with a sample of 103 patients. The following variables were studied: diagnosed oncohematological disease, probable diagnosis of inborn error of immunity and alarm signs of primary immunodeficiency.  Results:  the diagnosis of some oncological disease reached 87,4 %. Five patients were found with a probable diagnosis of an inborn error of immunity (Fanconi's anemia and Medullary Aplasia); 54,5 % of non-leukemic patients and only 24,1 % of leukemic patients had at least one and up to three alarm signs for immunodeficiency.  Conclusions:  the Jeffrey Modell Foundation alarm signs for the diagnosis of primary immunodeficiencies were not useful in patients with hematopathies; therefore other criteria for the identification of these disorders could be implemented. These patients should be re-evaluated by the provincial immunology group with a view to the diagnosis of inborn errors of immunity and their comprehensive treatment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[DIAGNÓSTICO]]></kwd>
<kwd lng="es"><![CDATA[HEMATOLOGÍA]]></kwd>
<kwd lng="es"><![CDATA[ONCOLOGÍA]]></kwd>
<kwd lng="en"><![CDATA[DIAGNOSIS]]></kwd>
<kwd lng="en"><![CDATA[HEMATOLOGY]]></kwd>
<kwd lng="en"><![CDATA[ONCOLOGY]]></kwd>
</kwd-group>
</article-meta>
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