<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942022000300016</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Alteraciones genitales en la infección por leptospiras en ratas Wistar gestadas]]></article-title>
<article-title xml:lang="en"><![CDATA[Genital alterations in leptospiras infection in pregnant Wistar rats]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mosquera-Escobar]]></surname>
<given-names><![CDATA[Mariela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Armas-González]]></surname>
<given-names><![CDATA[Eilín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarez-González]]></surname>
<given-names><![CDATA[Katerinne]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Otero]]></surname>
<given-names><![CDATA[Madelen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Alonso]]></surname>
<given-names><![CDATA[Margot]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pino]]></surname>
<given-names><![CDATA[Rafaela Díaz-del]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Facultad de Ciencias Médicas &#8220;Dr. Ernesto Che Guevara de la Serna&#8221; ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>26</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942022000300016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942022000300016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942022000300016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la leptospirosis en Cuba se presenta de forma endémica, y a veces de forma epidémica, por lo que es un problema de salud. Su efecto sobre los genitales internos, en gestantes, ha sido poco tratado por los investigadores.  Objetivo:  describir las principales alteraciones en los genitales internos de ratas Wistar gestadas infestadas por leptospiras.  Métodos: se realizó un estudio experimental en ratas Wistar preñadas: siete grupos con tres animales cada uno: un control negativo y seis casos con dosis de una concentración bacteriana de 300 millones de Leptospiras por mL; se inocularon dos mililitros a cada animal al cuarto día de gestadas por 17 meses. Se tomaron los genitales internos de todas las ratas el día 20 de la gestación, estos fueron procesados en parafina y teñidos con hematoxilina/eosina.  Resultados:  se observaron alteraciones en útero, ovarios y trompas; el mayor número de lesiones se presentaron en útero mientras que en ovarios y trompas se visualizaron la misma cantidad de lesiones.  Conclusiones:  la leptospirosis infectó los genitales internos con la producción de quistes, necrosis, abscesos, ooforitis y microhemorragias en ovarios; congestión vascular y hemorragias en las trompas uterinas y endometritis, hemorragias, miometritis, piometristis, perimetritis y congestión vascular en el útero. Predominaron las alteraciones congestivas y hemorrágicas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  leptospirosis in Cuba occurs endemically, and sometimes epidemically, making it a health problem. Its effect on internal genitalia in pregnant women has been little treated by researchers.  Objective:  to describe the main alterations in the internal genitalia of pregnant Wistar rats infested by leptospiras.  Methods:  an experimental study was carried out in pregnant Wistar rats: 7 groups with three animals each: 1 negative control and 6 cases with doses of a bacterial concentration of 300 million Leptospira per mL; each animal was inoculated with two milliliters on the fourth day of pregnancy for 17 months. The internal genitalia of all rats were taken on day 20 of gestation, processed in kerosene and stained with hematoxylin/eosin.  Results:  alterations were observed in the uterus, ovaries and tubes; the greatest number of lesions was present in the uterus while the same number of lesions was visualized in the ovaries and tubes.  Conclusions:  leptospirosis infected the internal genitalia producing cysts, necrosis, abscesses, oophoritis and microhemorrhages in the ovaries; vascular congestion and hemorrhages in the uterine tubes and endometritis, hemorrhages, myometritis, pyometristis, perimetritis and vascular congestion in the uterus. Congestive and hemorrhagic alterations predominated.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[LEPTOSPIROSIS]]></kwd>
<kwd lng="es"><![CDATA[LEPTOSPIRA]]></kwd>
<kwd lng="es"><![CDATA[ÚTERO]]></kwd>
<kwd lng="es"><![CDATA[TROMPAS UTERINAS]]></kwd>
<kwd lng="es"><![CDATA[OVARIOS]]></kwd>
<kwd lng="es"><![CDATA[RATAS WISTAR]]></kwd>
<kwd lng="en"><![CDATA[LEPTOSPIROSIS]]></kwd>
<kwd lng="en"><![CDATA[LEPTOSPIRA]]></kwd>
<kwd lng="en"><![CDATA[UTERUS]]></kwd>
<kwd lng="en"><![CDATA[FALLOPIAN TUBES]]></kwd>
<kwd lng="en"><![CDATA[OVARY]]></kwd>
<kwd lng="en"><![CDATA[RATS, WISTAR]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Díaz Alfonso]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Padrón González]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Lorenzo Díaz]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leptospirosis humana: una estrategia de superación]]></article-title>
<source><![CDATA[Rev Ciencias Médicas]]></source>
<year>2018</year>
<volume>22</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calderón-Sierra]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[Jaimes-Bernal]]></surname>
<given-names><![CDATA[CP]]></given-names>
</name>
<name>
<surname><![CDATA[Pedraza-Bernal]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comportamiento epidemiológico de la leptospirosis humana en Colombia, 2012-2016]]></article-title>
<source><![CDATA[Rev Cubana Med Trop]]></source>
<year>2019</year>
<volume>71</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ricardo]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Monje]]></surname>
<given-names><![CDATA[LD]]></given-names>
</name>
<name>
<surname><![CDATA[Landolt]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Chiani]]></surname>
<given-names><![CDATA[YT]]></given-names>
</name>
<name>
<surname><![CDATA[Schmeling]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
<name>
<surname><![CDATA[Beldoménico]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primer informe de Leptospira interrogans en el roedor sigmodontino Scapteromys aquaticus]]></article-title>
<source><![CDATA[Rev Panam Salud Pública]]></source>
<year>2018</year>
<volume>42</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bautista]]></surname>
<given-names><![CDATA[TB]]></given-names>
</name>
<name>
<surname><![CDATA[Bulla]]></surname>
<given-names><![CDATA[CD]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[BH]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Pulido]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leptospirosis: enfermedad de importancia en salud pública]]></article-title>
<source><![CDATA[Rev Colombiana Cienc Anim. Recia.]]></source>
<year>2019</year>
<volume>11</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carranza Zamora]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Chang Fonseca]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Gutierrez López]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leptospirosis y enfermedad de Weil]]></article-title>
<source><![CDATA[Rev.méd.sinerg]]></source>
<year>2020</year>
<volume>5</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aranzazu Ceballos]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Apraez Henao]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Ortiz Marín]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leptospirosis en pediatría, un diagnóstico a tener en cuenta]]></article-title>
<source><![CDATA[Rev. chil. infectol]]></source>
<year>2020</year>
<volume>37</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Selvarajah]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ran]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Roberts]]></surname>
<given-names><![CDATA[NW]]></given-names>
</name>
<name>
<surname><![CDATA[Nair]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[(2021) Leptospirosis in pregnancy: A systematic review]]></article-title>
<source><![CDATA[PLoS Negl Trop Dis]]></source>
<year>2021</year>
<volume>15</volume>
<numero>9</numero>
<issue>9</issue>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gompf]]></surname>
<given-names><![CDATA[SG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drugs and Diseases: Infections diseases]]></article-title>
<source><![CDATA[Leptospirosis Medscape]]></source>
<year>2021</year>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lemus Quintana]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Cabezas Alfonso]]></surname>
<given-names><![CDATA[HC]]></given-names>
</name>
<name>
<surname><![CDATA[Zaldivar Garit]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Armas González]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Ramos Chang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Observaciones clínico patológicas en ratas Wistar gestadas infectadas experimentalmente con leptospiras]]></article-title>
<source><![CDATA[Rev Ciencias Médicas]]></source>
<year>2017</year>
<volume>21</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Loureiro]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Lilenbaum]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[(2020). Genital bovine leptospirosis: A new look for an old disease]]></article-title>
<source><![CDATA[Theriogenology]]></source>
<year>2019</year>
<volume>141</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández-Cabezas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leptospirosis humana: un abordaje epidemiológico desde los factores ambientales]]></article-title>
<source><![CDATA[Revista Cubana de Medicina General Integral]]></source>
<year>2017</year>
<volume>33</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="book">
<collab>Ministerio de Salud Pública República de Cuba</collab>
<source><![CDATA[Categoria]]></source>
<year>2022</year>
<publisher-loc><![CDATA[Cuba ]]></publisher-loc>
<publisher-name><![CDATA[PAMI]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andre -Fontaine]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Aviat]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Thorin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Waterborne Leptospirosis: Survival and Preservation of the Virulence of Pathogenic Leptospira spp. in Fresh Water]]></article-title>
<source><![CDATA[Curr Microbiol]]></source>
<year>2015</year>
<volume>71</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cedillo Sánchez]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
<name>
<surname><![CDATA[Banda Ruiz]]></surname>
<given-names><![CDATA[VM]]></given-names>
</name>
<name>
<surname><![CDATA[Morales Salinas]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Villagómez Amezcua]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Asociación de quistes foliculares ováricos con la presencia de anticuerpos y agentes causantes de las principales enfermedades infecciosas reproductivas en vacas]]></article-title>
<source><![CDATA[Rev Aban Veterin]]></source>
<year>2012</year>
<volume>2</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Romero Becerra]]></surname>
<given-names><![CDATA[LR]]></given-names>
</name>
<name>
<surname><![CDATA[Veloza]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leptospirosis bovina como causa de enfermedad reproductiva]]></article-title>
<source><![CDATA[Rev Sist Prod Agroecol]]></source>
<year>2014</year>
<volume>5</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>28</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez-Sáenz]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
<name>
<surname><![CDATA[Brieva-Rico]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz-Quiroga]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Endometritis supurativa en una tití gris (Saguinus leucopus) en cautiverio: reporte de caso]]></article-title>
<source><![CDATA[Rev Med Vet]]></source>
<year>2020</year>
<numero>41</numero>
<issue>41</issue>
<page-range>57-69</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
