<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1726-6718</journal-id>
<journal-title><![CDATA[Revista Cubana de Anestesiología y Reanimación]]></journal-title>
<abbrev-journal-title><![CDATA[Rev cuba anestesiol reanim]]></abbrev-journal-title>
<issn>1726-6718</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1726-67182020000200005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Ozonoterapia sistémica en pacientes diabéticos insulinodependientes con dolor neuropático]]></article-title>
<article-title xml:lang="en"><![CDATA[Systemic ozone therapy in insulin-dependent diabetic patients with neuropathic pain]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Guirola]]></surname>
<given-names><![CDATA[Yakelín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lombas Rojas]]></surname>
<given-names><![CDATA[Adrian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico Quirúrgico &#8220;Hermanos Ameijeiras&#8221;  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>19</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1726-67182020000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1726-67182020000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1726-67182020000200005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Con frecuencia, los pacientes diabéticos presentan dolor neuropático como complicación de su enfermedad.  Objetivo:  Identificar las ventajas de la ozonoterapia sistémica en pacientes diabéticos insulinodependientes con dolor neuropático.  Métodos:  Se realizó un estudio descriptivo en diabéticos insulinodependientes con dolor neuropático que acudieron a la Clínica del Dolor del Hospital Clínico Quirúrgico &#8220;Hermanos Ameijeiras&#8221; entre febrero de 2014 hasta enero de 2019. A todos se les cuantificó el dolor, la presencia de parestesias, la fuerza muscular, el reflejo aquiliano y la hemoglobina glicosilada. Se administraron 15 sesiones de ozono vía rectal y 6 de autohemoterapia mayor. Se compararon los resultados de la primera sesión y en la última (8 semanas de tratamiento).  Resultados:  El 45,3 % tenían 60 años o más, 59 % eran del sexo femenino y 89,3 % tenían 15 o más años de evolución de la diabetes. En la primera consulta la intensidad del dolor en 100 % osciló entre 7 y 10 de la escala numérica verbal y todos presentaron parestesias. En 59,3 % existió disminución de la fuerza muscular, 62 % presentó reflejo aquiliano disminuido y 88 % hemoglobina glicosilada mayor o igual a 12 %. Estos síntomas mejoraron a las ocho semanas.  Conclusiones:  Las probadas propiedades analgésicas y antiinflamatorias del ozono lo convierten en la actualidad en una herramienta terapéuticas de las más eficientes para el control del dolor crónico en pacientes diabéticos insulinodependientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Frequently, diabetic patients present neuropathic pain as a complication of their disease.  Objective:  To identify the advantages of systemic ozone therapy for insulin-dependent diabetic patients with neuropathic pain.  Methods:  A descriptive study was carried out with insulin-dependent diabetic patients with neuropathic pain who attended the Pain Clinic of Hermanos Ameijeiras Clinical-Surgical Hospital between February 2014 until January 2019. All of them were quantified pain, the presence of paresthesias, muscle strength, ankle jerk reflex, and glycosylated hemoglobin. The patients received fifteen sessions of rectal ozone and six sessions of major self-hemotherapy. We compared the outcomes after the first session and after the last one (eight weeks).  Results:  45.3% were 60 years or older, 59% were female, and 89.3% had a natural history of diabetes of 15 years or more. In the first hospital visit, the intensity of 100% pain ranged between 7 and 10 according to the verbal numeric scale, and all presented paresthesias. In 59.3%, there was a decrease in muscle strength, 62% had decreased ankle jerk reflex, and 88% had glycosylated hemoglobin higher than or equal to 12%. These symptoms improved at week eight.  Conclusions:  The proven analgesic and anti-inflammatory properties of ozone make it currently a therapeutic tool among the most efficient for controlling chronic pain in insulin-dependent diabetic patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[diabetes mellitus insulinodependiente]]></kwd>
<kwd lng="es"><![CDATA[dolor neuropático]]></kwd>
<kwd lng="es"><![CDATA[ozono-terapia]]></kwd>
<kwd lng="en"><![CDATA[insulin-dependent diabetes mellitus]]></kwd>
<kwd lng="en"><![CDATA[neuropathic pain]]></kwd>
<kwd lng="en"><![CDATA[ozone therapy]]></kwd>
</kwd-group>
</article-meta>
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