<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2019000400634</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Trastornos inmunitarios en dos pacientes pediátricos con Toxocariasis]]></article-title>
<article-title xml:lang="en"><![CDATA[Immune disorders in two pediatric patients with Toxocariasis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ínsua Arregui]]></surname>
<given-names><![CDATA[Concepción]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[Jesús Salim Burón]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[Eric Montero]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Hospital Pediátrico Universitario "William Soler" ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Instituto Cubano de Oftalmología "Ramón Pando Ferrer" ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>18</volume>
<numero>4</numero>
<fpage>634</fpage>
<lpage>639</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2019000400634&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2019000400634&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2019000400634&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La Toxocariasis es una zoonosis causada por nemátodos del género Toxocara. Accidentalmente el ser humano ingiere los huevos larvados y ocurren reacciones inflamatorias. En pacientes con afecciones inmunológicas, la infección se manifiesta de forma más grave.  Objetivo:  Evaluar los trastornos inmunológicos de dos pacientes con Toxocariasis en el Hospital Pediátrico &#8220;William Soler&#8221;.  Presentación de casos:  Se presentan dos pacientes; una, de 5 años, con infecciones recurrentes respiratorias, y pérdida de visión del ojo izquierdo, y otro paciente de 14 años con neumonías recurrentes, diarreas frecuentes y disminución de la agudeza visual en ambos ojos. En la paciente, en el fondo de ojo encontramos leucocoria y granuloma y presentó disminución marcada de la agudeza visual. Se realizó cuantificación de inmunoglobulinas séricas G, A, M por turbidimetría, y E por ELISA, subpoblaciones linfocitarias B, T y de células asesinas naturales por citometría de flujo y Test de ELISA para Toxocara canis, positivo en ambos casos, en la paciente IgA 0 g/l (ausente), e IgE 720 UI/mL (elevada). Subpoblaciones linfocitarias TCD3+/CD8+ (5.57%), y B CD19 (11,06%) disminuidas. En el segundo caso, IgE 810 UI/mL (elevada) y resto normales. Subpoblaciones linfocitarias TCD3+/CD8+ (4.86 %), y NKCD 56 (5,04%) disminuidas.  Conclusiones: Se diagnosticó inmunodeficiencia combinada T-B en un paciente e inmunodeficiencia celular en el otro. Después del tratamiento con Hebertrans mejoraron las infecciones y se detuvo la pérdida de agudeza visual. La evolución tórpida y complicaciones se correspondieron con el deterioro inmunológico de estos pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Toxocariasisis is a zoonosis caused by nematodes of the genus Toxocara. Accidentally, the human being ingests larvae eggs which causes inflammatory reactions. In patients with immunological conditions, the infection is expressed in the most severe form.  Objective: To evaluate the immunological disorders of two patients with Toxocariasis in William Soler Pediatric Hospital.  Case presentation: We present two patients: a 5 years old girl with recurrent respiratory infections and loss of vision on the left eye and a 14 years old boy with recurrent pneumonia, frequent diarrhea and decreased visual acuity in both eyes. After performing a fundus examination to the first patient, leukocoria, granuloma and a marked decrease in visual acuity were found. Quantification of serum immunoglobulins G, A, M were determined by a turbidimetric method, and E was determined by ELISA; B-lymphocyte subpopulations and T lymphocytes and natural killer cells were also determined by flow cytometry and Elisa test, which were positive for Toxocara canis in both cases. In the first patient IgA was 0 g / l (absent), and IgE was 720 IU / mL (elevated). TCD3 + / CD8 + lymphocyte subpopulations (5.57%), and decreased B CD19 (11.06%) were also found. In the second case, IgE was 810 IU / mL (elevated) and the others were normal. TCD3 + / CD8 + lymphocyte subpopulations (4.86%), and NKCD56 (5.04%) were decreased.  Conclusions:  Combined T-B immunodeficiency was diagnosed in a patient, and cellular immunodeficiency was diagnosed in the other one. Infections improved in both patients and the loss of visual acuity stopped after treatment with Hebertrans. The torpid evolution and complications corresponded with the immunological deterioration of these patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Toxocariasis]]></kwd>
<kwd lng="es"><![CDATA[inmunodeficiencia]]></kwd>
<kwd lng="es"><![CDATA[zoonosis]]></kwd>
<kwd lng="es"><![CDATA[trastornos inmunológicos]]></kwd>
<kwd lng="en"><![CDATA[Toxocariasis]]></kwd>
<kwd lng="en"><![CDATA[zoonosis]]></kwd>
<kwd lng="en"><![CDATA[Immunodeficiency]]></kwd>
<kwd lng="en"><![CDATA[immunological disorder]]></kwd>
</kwd-group>
</article-meta>
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