<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2020000600006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización clínica e inmunológica del Asma Neutrofílica]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical and immunological characterization of Neutrophilic asthma]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Burón Hernández]]></surname>
<given-names><![CDATA[Jesús Salím]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Insua Arregui]]></surname>
<given-names><![CDATA[Concepción]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lazo López]]></surname>
<given-names><![CDATA[Mercedes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Pediátrico Universitario &#8220;William Soler&#8221; Departamento de Alergia e Inmunología ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2020</year>
</pub-date>
<volume>19</volume>
<numero>5</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2020000600006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2020000600006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2020000600006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El asma bronquial es una enfermedad mucho más compleja de lo que inicialmente se consideraba, es multifactorial y se manifiesta en diferentes fenotipos clínicos, entre ellos, el asma neutrofílica.  Objetivo:  Caracterizar clínica e inmunológicamente el asma neutrofílica.  Material y Métodos:  Se realizó una revisión bibliográfica actualizada. Se empleó el motor de búsqueda Google Académico y se consultaron artículos de libre acceso en las bases de datos Pubmed y Scielo y se revisaron 50 artículos.  Desarrollo:  Los neutrófilos están presentes en las vías respiratorias del paciente con asma, se activan y pueden liberar mediadores que promueven y prolongan los síntomas del asma, la presencia de neutrófilos puede ser mediada por interleucina 17(IL-17), la hipótesis de cambios en la microbiota, la obesidad y las infecciones, constituyen elementos primordiales en este tipo de enfermedad. Para aliviar los síntomas de estos pacientes, se necesita una terapia dirigida a disminuir la inflamación dominada por neutrófilos.  Conclusiones:  El asma neutrofílica es una enfermedad crónica fenotípicamente heterogénea de las vías respiratorias, que implica la participación de numerosas células inflamatorias y más de cien mediadores con múltiples efectos inflamatorios, como el broncoespasmo, la exudación plasmática, la hipersecreción de moco y la activación sensorial. Actualmente existen pocas drogas dirigidas contra la inflamación neutrofílica y la mayoría se encuentran en estudio con el objetivo de aliviar y mejorar las condiciones de vida de cada uno de los pacientes que sufren esta enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Bronchial asthma is a much more complex disease than initially thought; it is multifactorial and manifests itself in different clinical phenotypes; among them, we can mention neutrophilic asthma.  Objective:  To characterize neutrophilic asthma from a clinical and immunological point of view.  Material and methods:  An updated bibliographic review was made. Google Scholar search engine was used; free access articles were consulted in PubMed and SciELO databases and 50 of them were reviewed.  Development:  Neutrophils are present in the respiratory tract of patients suffering from asthma; once those neutrophils are activated, they can release mediators that promote and prolong the symptoms of the disease. The presence of neutrophils can be mediated by IL-17. The hypothesis on changes in the microbiota, obesity and infections are key points in this kind of disease. To alleviate the symptoms of these patients, targeted therapy for neutrophil-dominated inflammation is needed.  Conclusions:  Neutrophilic asthma is a phenotypically heterogeneous chronic disease of the respiratory tract which involves numerous inflammatory cells and more than a hundred mediators with multiple inflammatory effects such as bronchospasm, plasma exudation, mucus hypersecretion and sensory activation. Currently, there are few drugs targeting neutrophilic inflammation and most of them are under study with the aim of alleviating and improving the living conditions in patients suffering from this disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Asma]]></kwd>
<kwd lng="es"><![CDATA[inmunológico]]></kwd>
<kwd lng="es"><![CDATA[neutrófilos]]></kwd>
<kwd lng="es"><![CDATA[asma neutrofílica]]></kwd>
<kwd lng="en"><![CDATA[Asthma]]></kwd>
<kwd lng="en"><![CDATA[immunological]]></kwd>
<kwd lng="en"><![CDATA[neutrophils]]></kwd>
<kwd lng="en"><![CDATA[neutrophilic asthma]]></kwd>
</kwd-group>
</article-meta>
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