<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2020000700008</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Situación actual de Cannabis sativa, beneficios terapéuticos y reacciones adversas]]></article-title>
<article-title xml:lang="en"><![CDATA[Current status of Cannabis sativa; therapeutic benefits and adverse reactions]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Venegas]]></surname>
<given-names><![CDATA[Elia de la Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fontaine-Ortiz]]></surname>
<given-names><![CDATA[Julio Ernesto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Facultad de Ciencias Médicas &#8220;Finlay Albarrán&#8221; ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Facultad de Ciencias Médicas &#8220;Comandante Manuel Fajardo&#8221; ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Clínico Quirúrgico &#8220;Comandante Manuel Fajardo&#8221;  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>19</volume>
<numero>6</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2020000700008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2020000700008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2020000700008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  En la actualidad, uno de los temas más polémicos que involucra en gran proporción al campo de la Medicina es el uso terapéutico de la marihuana y su legalización. Esta planta de reconocimiento milenario ha desatado en las últimas décadas disímiles de controversias dado el descubrimiento del sistema endocannabinoide que revolucionó la investigación sobre ella.  Objetivo:  Describir la situación actual del cannabis, sus beneficios terapéuticos y sus efectos adversos.  Material y métodos:  Se realizó una exhaustiva búsqueda y revisión empleando los Descriptores en Ciencias de la Salud, en idioma inglés y español, consultando las bases de datos Pubmed, Scielo, Lilacs, Cochrane Library y Web of Science, para los últimos 10 años, empleándose un total de 45 artículos como referencias bibliográficas.  Desarrollo:  Al Cannabis se le han atribuido efectos farmacológicos, tales como: antinociceptivo, antiepiléptico, inmunosupresivo, antiemético, estimulante del apetito, antimicrobiano, antiinflamatorio y neuroprotector. A su vez, presenta disímiles reacciones adversas como son la predisposición a varios tipos de cáncer, empeoramiento de desórdenes mentales, dificultades en el aprendizaje y el rendimiento escolar, que constituye una droga portera, entre otros. A pesar de las tendencias legalizadoras no son suficientes las razones para la legalización de esta droga, cuando su principal blanco resulta ser los adolescentes, donde los daños neurológicos que causa son irreversibles.  Conclusiones:  Se debe continuar explorando las potencialidades terapéuticas de los cannabinoides a partir de la elaboración de productos farmacológicos bien dosificados y controlados, pues el riesgo de sus efectos adversos es innegable y contundente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Currently, one of the most controversial issues that greatly involves the medical field is the therapeutic use and legalization of marijuana. This millennial recognition has led to different controversies in recent decades due to the discovery of the endocannabinoid system which has revolutionized the process of research on this topic.  Objective:  To describe the current situation of cannabis, its therapeutic benefits and adverse effects.  Material and methods:  An in-depth search and review was carried out using Health Sciences descriptors in English and Spanish. A search was carried out in PubMed, SciELO, Lilacs, Cochrane Library and Web of Science databases. Publications from the last 10 years were consulted, using a total of 45 articles as bibliographic references.  Development:  Some pharmacological effects such as antinociceptive, antiepileptic, immunosuppressive, antiemetic, appetite stimulant, antimicrobial, anti-inflammatory and neuroprotective ones have been attributed to Cannabis. In turn, it presents dissimilar adverse reactions such as predisposition to various types of cancer, worsening of mental disorders, and difficulties with learning and school performance. Cannabis, among others, is considered a starter drug. Despite the trend towards legalization, there are not enough reasons for the legalization of this drug. Its main target turns out to be the adolescents, among which the neurological damage it causes is irreversible.  Conclusions:  The therapeutic potential of cannabinoids should continue to be explored from the production of well dosed and controlled pharmacological products, since the risk of their adverse effects are undeniable and overwhelming.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Abuso de la marihuana]]></kwd>
<kwd lng="es"><![CDATA[Cannabinoides]]></kwd>
<kwd lng="es"><![CDATA[Cannabis sativa]]></kwd>
<kwd lng="es"><![CDATA[dependencia al Cannabis]]></kwd>
<kwd lng="es"><![CDATA[marihuana]]></kwd>
<kwd lng="es"><![CDATA[uso de la marihuana]]></kwd>
<kwd lng="en"><![CDATA[Marijuana abuse]]></kwd>
<kwd lng="en"><![CDATA[Cannabinoids]]></kwd>
<kwd lng="en"><![CDATA[Cannabis sativa]]></kwd>
<kwd lng="en"><![CDATA[Cannabis dependence]]></kwd>
<kwd lng="en"><![CDATA[marijuana]]></kwd>
<kwd lng="en"><![CDATA[marijuana use]]></kwd>
</kwd-group>
</article-meta>
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