<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2021000600006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tratamiento y supervivencia de pacientes con melanoma en el Instituto Nacional de Oncología y Radiobiología]]></article-title>
<article-title xml:lang="en"><![CDATA[Treatment and survival of patients with melanoma at the National Institute of Oncology and Radiobiology]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez Lobaina]]></surname>
<given-names><![CDATA[Alexis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mir Espinosa]]></surname>
<given-names><![CDATA[Yanelis Longina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Docente Clínico Quirúrgico &#8220;10 de Octubre&#8221;  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Oncología y Radiobiología  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>20</volume>
<numero>6</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2021000600006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2021000600006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2021000600006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: El melanoma es una enfermedad potencialmente mortal, asociada a una alta morbilidad y mortalidad, por el alto riesgo de metástasis nodal regional y a distancia.  Objetivo:  Describir las características demográficas, clínico-patológicas, terapéutica, instaurada en la serie estudiada y la supervivencia en los pacientes evaluados.  Material y Métodos: Se realizó un estudio descriptivo y retrospectivo, en 79 pacientes con melanoma localmente avanzado estadio III, en el período de 2003 a 2018. Se realizó una revisión documental de historias clínicas e informes de anatomía patológica para la obtención de los datos.  Resultados: En relación con las variables clínico-patológicas de los pacientes, 51,9 % fueron hombres y el subtipo histológico de extensión superficial representó 44,1 % de la muestra. Un 64,6 % se diagnosticó en etapa IIIB y 35,4 % en etapa IIIC. La exéresis de la lesión primaria como único tratamiento se realizó en 35,1 % de los pacientes y el uso del Interferón alfa en 80 % para los que recibieron inmunoterapia. Hasta el momento del análisis 67 pacientes, 84,8 %, habían progresado y un 83,5 % fallecieron. La mediana de supervivencia libre de progresión se estimó en 1,0 año y la de la supervivencia global en 1,10 años.  Conclusiones:  En la serie de pacientes evaluados predominó el subtipo extensión superficial. Predominó discretamente el sexo masculino y la etapa IIIB. La modalidad terapéutica más indicada fue la exéresis de la lesión primaria; tanto la supervivencia libre de progresión como la global fueron bajas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Melanoma is a potentially lethal disease that is associated with a high morbidity and mortality rates due to the high risk of regional or distant nodal metastasis.  Objective: To describe the demographic and clinical-pathological characteristics and the therapeutic procedure, as well as to determine the survival in the patients evaluated in the study.  Material and Methods:  A descriptive and retrospective study was carried out in a group of seventy-nine patients suffering from locally advanced stage III melanoma during 2003-2018 period. Data were taken from the documentary review of clinical histories and the records of the Department of Pathological Anatomy.  Results:  Regarding the clinical-pathological variables, men comprised 51,9 % of the sample, and the superficial extension in the histological subtype represented 44,1 % of the sample. About 64,6 % and 35,4 % of patients were diagnosed in stage IIIB and stage IIIC, respectively. The removal of the primary lesion was performed as the only treatment option in 35,1 % of the patients, and Interferon Alfa was used in 80 % of those who received immunotherapy. Up until the analysis of 67 patients, it was demonstrated that 84,8 % of them had improved while 83,5 % had died. The median progression-free survival was 1,0 years and the global survival was 1,10 years.  Conclusions:  The superficial subtype predominated in the group of patients studied. There was a discrete prevalence of males and stage IIIB. The most commonly indicated therapeutic procedure was the removal of the primary lesion. Both the median progression-free survival and the global one were low.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cáncer de piel]]></kwd>
<kwd lng="es"><![CDATA[melanoma]]></kwd>
<kwd lng="es"><![CDATA[melanoma localmente avanzado]]></kwd>
<kwd lng="es"><![CDATA[inmunoterapia]]></kwd>
<kwd lng="en"><![CDATA[Skin cancer]]></kwd>
<kwd lng="en"><![CDATA[melanoma]]></kwd>
<kwd lng="en"><![CDATA[locally advanced melanoma]]></kwd>
<kwd lng="en"><![CDATA[immunotherapy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Infante Carbonell]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[González Calzadilla]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Jaén Infante]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Valle Piñera S Melanoma cutáneo: algunas consideraciones actuales]]></article-title>
<source><![CDATA[MEDISAN]]></source>
<year>2019</year>
<volume>23</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>146-64</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garbe]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Peris]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Hauschild]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Saiag]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Middleton]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bastholt]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diagnosis and treatment of melanoma European consensus-based interdisciplinary guideline e Update 2016]]></article-title>
<source><![CDATA[Euro J Cancer]]></source>
<year>2016</year>
<volume>63</volume>
<page-range>201-17</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schadendorf]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Van Akkooi]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Melanoma diagnóstico y tratamiento]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2018</year>
<volume>392</volume>
<page-range>971-84</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Álvarez Lobaina]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Caracterización de pacientes con melanoma localmente avanzado en el Instituto Nacional de Oncología y Radiobiología]]></article-title>
<source><![CDATA[Folia Dermatológica Cubana]]></source>
<year>2020</year>
<volume>14</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Michielin]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Hoeller]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gaining momentum New options and opportunities for the treatment of advanced melanoma]]></article-title>
<source><![CDATA[Cancer Treat Rev]]></source>
<year>2015</year>
<volume>41</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>660-70</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gimotty]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<name>
<surname><![CDATA[Elder]]></surname>
<given-names><![CDATA[DE]]></given-names>
</name>
<name>
<surname><![CDATA[Fraker]]></surname>
<given-names><![CDATA[DL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Identification of high-risk patients among those diagnosed with thin cutaneous melanomas]]></article-title>
<source><![CDATA[J Clin Oncol]]></source>
<year>2017</year>
<volume>25</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1129-34</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nieweg]]></surname>
<given-names><![CDATA[OE]]></given-names>
</name>
<name>
<surname><![CDATA[Gallegos Hernández]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[La cirugía en melanoma cutáneo maligno y las nuevas drogas]]></article-title>
<source><![CDATA[Academia Mexicana de Cirugía]]></source>
<year>2015</year>
<volume>83</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>175-80</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mahul]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
</person-group>
<source><![CDATA[AJCC Cancer Staging Manual]]></source>
<year>2002</year>
<edition>4</edition>
<publisher-loc><![CDATA[New York ]]></publisher-loc>
<publisher-name><![CDATA[Springer Science an Business Media]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Camacho Limas]]></surname>
<given-names><![CDATA[CP]]></given-names>
</name>
<name>
<surname><![CDATA[Gerson Cwilich]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Góngora Jurado]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Villalobos Prieto]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Blanco Vázquez]]></surname>
<given-names><![CDATA[YC]]></given-names>
</name>
<name>
<surname><![CDATA[López Riverol]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Actualidades para el tratamiento del melanoma metastásico, estado del arte]]></article-title>
<source><![CDATA[An Med (Mex)]]></source>
<year>2017</year>
<volume>62</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>196-207</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mulliken]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Russak]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rigel]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Effect of Sunscreen in Melanoma risk]]></article-title>
<source><![CDATA[Dermatol Clin]]></source>
<year>2014</year>
<volume>30</volume>
<page-range>369-76</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="book">
<collab>Dirección de Registros Médicos y Estadísticas de Salud</collab>
<source><![CDATA[Anuario Estadístico de Salud 2019]]></source>
<year>2020</year>
<publisher-loc><![CDATA[La Habana ]]></publisher-loc>
<publisher-name><![CDATA[MINSAP]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berwick]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Erdei]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Hay]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Melanoma Epidemiology and Public Health]]></article-title>
<source><![CDATA[Dermatol Clin]]></source>
<year>2015</year>
<volume>27</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>205-14</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez Said]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Cuéllar Hubbe]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Barrón Velázquez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Padilla]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Herrera Gómez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[López Graniel]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epidemiology of cutaneous melanoma in Mexico (1982-2002)]]></article-title>
<source><![CDATA[Eur J Surg Oncol]]></source>
<year>2014</year>
<volume>30</volume>
<page-range>163</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El primer Consenso Nacional de Expertos en Melanoma]]></article-title>
<source><![CDATA[Gac Mex Oncol]]></source>
<year>2015</year>
<volume>4</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>11-3</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="book">
<collab>Oficina Nacional de Estadística e Información</collab>
<source><![CDATA[El Color de la Piel según el Censo de Población y Viviendas de 2012]]></source>
<year>2016</year>
<publisher-loc><![CDATA[La Habana ]]></publisher-loc>
<publisher-name><![CDATA[Centro de Estudios de Población y Desarrollo]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arora]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Attwood]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Common Skin Cancers and Their Precursors]]></article-title>
<source><![CDATA[Surg Clin N Am]]></source>
<year>2014</year>
<volume>82</volume>
<page-range>703-12</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Curin]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Fridlyand]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kageshita]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Patel]]></surname>
<given-names><![CDATA[HN]]></given-names>
</name>
<name>
<surname><![CDATA[Busam]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Kutzner]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Distinct sets of genetic alterations in melanoma]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2015</year>
<volume>353</volume>
<numero>20</numero>
<issue>20</issue>
<page-range>2135-47</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quiroga Mendieta]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza López]]></surname>
<given-names><![CDATA[JN]]></given-names>
</name>
<name>
<surname><![CDATA[Ramos Loza]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Melanoma maligno metatastásico reporte de caso]]></article-title>
<source><![CDATA[Rev Med La Paz]]></source>
<year>2017</year>
<volume>23</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>40-4</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramos Álvarez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz Leal]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez Dueñas]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Crocker Sandoval]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez Tenorio]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Orendain Koch]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Melanoma en la práctica privada en México un diagnóstico oportuno]]></article-title>
<source><![CDATA[Dermatología Revista Mexicana]]></source>
<year>2015</year>
<volume>59</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>89-97</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yabor Palomo]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz Pérez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Peña Pérez]]></surname>
<given-names><![CDATA[OR]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez Yabor]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Morales Fontaine]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Melanoma maligno cutáneo en pacientes de la provincia de Las Tunas]]></article-title>
<source><![CDATA[Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta]]></source>
<year>2015</year>
<volume>40</volume>
<numero>12</numero>
<issue>12</issue>
</nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tuong]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Armstrong]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Melanoma Epidemiology, Diagnosis, Treatment, and Outcomes]]></article-title>
<source><![CDATA[Dermatol Clin]]></source>
<year>2012</year>
<volume>30</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>113-24</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Herrera]]></surname>
<given-names><![CDATA[NE]]></given-names>
</name>
<name>
<surname><![CDATA[Aco]]></surname>
<given-names><![CDATA[AY]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Melanoma en México artículo de revisión]]></article-title>
<source><![CDATA[Revista de Especialidades Médico-Quirúrgicas]]></source>
<year>2014</year>
<volume>15</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>161-4</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gutiérrez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Experiencia Clínica en el tratamiento adyuvante de los pacientes con melanoma de tronco y extremidades estado III en un hospital del tercer mundo]]></article-title>
<source><![CDATA[Revista Colombiana de Cancerología]]></source>
<year>2015</year>
<volume>19</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>125-32</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="book">
<collab>NIH</collab>
<source><![CDATA[Melanoma: Tratamiento-para profesionales de salud]]></source>
<year>2015</year>
<publisher-loc><![CDATA[USA ]]></publisher-loc>
<publisher-name><![CDATA[Instituto Nacional del Cáncer de los Institutos Nacionales de la Salud de EE.UU]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Phan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Touzets]]></surname>
<given-names><![CDATA[SB]]></given-names>
</name>
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[BL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acral Lentiginous Melanoma Histopathological Prognotic Features of 121 cases]]></article-title>
<source><![CDATA[BR J Clinic Dermatol]]></source>
<year>2007</year>
<volume>157</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>311-8</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marchese]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Stringa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Valdés]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Factores pronósticos en el melanoma]]></article-title>
<source><![CDATA[Dermatol]]></source>
<year>2017</year>
<volume>23</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>3-12</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
