<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-5996</journal-id>
<journal-title><![CDATA[Revista Cubana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cuba Reumatol]]></abbrev-journal-title>
<issn>1817-5996</issn>
<publisher>
<publisher-name><![CDATA[Editorial CIMEQ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-59962019000200015</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La melatonina y su rol en los procesos inflamatorios]]></article-title>
<article-title xml:lang="en"><![CDATA[Melatonin and its role in inflammatory processes]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Costa]]></surname>
<given-names><![CDATA[Maricarmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Padrón González]]></surname>
<given-names><![CDATA[Alexander Ariel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Instituto de Ciencias Básicas y Preclínicas: &#8220;Victoria de Girón&#8221; Departamento de Inmunología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>21</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1817-59962019000200015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1817-59962019000200015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1817-59962019000200015&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La melatonina es una hormona neuroendocrina pleiotrópica, producida principalmente por la glándula pineal que regula el ritmo circadiano, es antiinflamatoria, inmunomoduladora, neuroprotectora, antioxidante. Se realizó una revisión sobre el tema empleando artículos de libre acceso en la base de datos Pubmed en el período de enero del 2013 a septiembre del 2018 con el objetivo de describir el rol de esta biomolécula en algunas enfermedades autoinmunes y reumatológicas, así como en otros procesos inflamatorios agudos y crónicos. La melatonina ha demostrado acciones favorables cuando se administra en enfermedades como la esclerosis múltiple, diabetes mellitus tipo l, cáncer. No obstante, puede empeorar las crisis en la artritis reumatoide.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Melatonin is a pleiotropic neuroendocrine hormone, produced mainly by the pineal gland that regulates the circadian rhythm, is anti-inflammatory, immunomodulatory, neuroprotective, antioxidant. A review on the subject was performed using articles of free access in the Pubmed database from January 2013 to September 2018 with the aim of describing the role of this biomolecule in some autoimmune and rheumatological diseases, as well as in other acute and chronic inflammatory processes. Melatonin has shown favorable actions when it is administered in diseases such as multiple sclerosis, diabetes mellitus type I, cancer. However, it can worsen crises in rheumatoid arthritis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[melatonina]]></kwd>
<kwd lng="es"><![CDATA[inflamación]]></kwd>
<kwd lng="es"><![CDATA[enfermedades autoinmunes]]></kwd>
<kwd lng="es"><![CDATA[enfermedades reumatológicas]]></kwd>
<kwd lng="en"><![CDATA[melatonin]]></kwd>
<kwd lng="en"><![CDATA[inflammation]]></kwd>
<kwd lng="en"><![CDATA[autoimmune diseases]]></kwd>
<kwd lng="en"><![CDATA[rheumatological diseases]]></kwd>
</kwd-group>
</article-meta>
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