<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-5996</journal-id>
<journal-title><![CDATA[Revista Cubana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cuba Reumatol]]></abbrev-journal-title>
<issn>1817-5996</issn>
<publisher>
<publisher-name><![CDATA[Editorial CIMEQ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-59962023000400021</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Neurolupus como forma de debut de lupus eritematoso sistémico en paciente masculino]]></article-title>
<article-title xml:lang="en"><![CDATA[Neurolupus as a debut form of systemic lupus erythematosus in a male patient]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Huaraca Morocho]]></surname>
<given-names><![CDATA[Brigette Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Buenaño Zambrano]]></surname>
<given-names><![CDATA[Verónica Monserrath]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abarca Carrasco]]></surname>
<given-names><![CDATA[Rodrigo Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Diago Alfes]]></surname>
<given-names><![CDATA[Zilma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Escuela Superior Politécnica de Chimborazo  ]]></institution>
<addr-line><![CDATA[Riobamba Chimborazo]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Chimborazo  ]]></institution>
<addr-line><![CDATA[Riobamba Chimborazo]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>25</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1817-59962023000400021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1817-59962023000400021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1817-59962023000400021&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El lupus eritematoso sistémico es una enfermedad inflamatoria sistémica y crónica que se caracteriza por una variada gama de manifestaciones clínicas secundaria al proceso inflamatorio mantenido como consecuencia de la afectación del funcionamiento del sistema inmune. Estas manifestaciones pueden afectar al sistema osteomioarticular (manifestaciones articulares), o presentarse en cualquier otro órgano o sistema de órgano (manifestaciones extraarticulares). En ocasiones, el debut de la enfermedad está marcado por la presencia de manifestaciones sistémicas de la enfermedad. El objetivo de esta investigación es presentar el caso clínico de un paciente masculino de 28 años de edad, que comienza con manifestaciones de tipo neurológicas que permiten, inicialmente la sospecha clínica y posteriormente, el diagnóstico definitivo de lupus eritematoso sistémico con componente neurológico. La presencia de cefaleas y un cuadro convulsivo tónico clónico, con positividad de anticuerpos y consumo de complemento fueron los principales componentes que permitieron confirmar el diagnóstico de la enfermedad. Se considera un caso necesario de compartir ya que aporta elementos importantes para el diagnóstico y tratamiento inicial del neurolupus, realizándose un abordaje integral del paciente por un grupo multidisciplinario. En el caso que se reporta la expresión de exacerbación de la enfermedad fue la presencia de las manifestaciones clínicas del bruxismo con trismo incluido. El proceso inflamatorio puede afectar cualquier estructura anatómica de la economía humana.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Systemic lupus erythematosus is a systemic and chronic inflammatory disease that is characterized by a wide range of clinical manifestations secondary to the inflammatory process maintained as a consequence of affecting the functioning of the immune system. These manifestations can affect the osteomyoarticular system (articular manifestations), or present in any other organ or organ system (extra-articular manifestations). Sometimes the onset of the disease is marked by the presence of systemic manifestations of the disease. The objective of this research is to present the clinical case of a 28-year-old male patient, who begins with neurological manifestations that allow, initially, clinical suspicion and later, the definitive diagnosis of systemic lupus erythematosus with a neurological component. The presence of headaches and a tonic-clonic seizure, with positive antibodies and consumption of complement were the main components that allowed confirming the diagnosis of the disease. It is considered a necessary case to share since it provides important elements for the diagnosis and initial treatment of neurolupus, carrying out a comprehensive approach to the patient by a multidisciplinary group. In the case that is reported, the expression of exacerbation of the disease was the presence of the clinical manifestations of bruxism with trismus included. The inflammatory process can affect any anatomical structure of the human economy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[enfermedad reumática]]></kwd>
<kwd lng="es"><![CDATA[lupus eritematoso sistémica]]></kwd>
<kwd lng="es"><![CDATA[inflamación]]></kwd>
<kwd lng="es"><![CDATA[neurolupus]]></kwd>
<kwd lng="en"><![CDATA[rheumatic disease]]></kwd>
<kwd lng="en"><![CDATA[systemic lupus erythematosus]]></kwd>
<kwd lng="en"><![CDATA[inflammation]]></kwd>
<kwd lng="en"><![CDATA[neurolupus]]></kwd>
</kwd-group>
</article-meta>
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