<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2078-7170</journal-id>
<journal-title><![CDATA[CorSalud]]></journal-title>
<abbrev-journal-title><![CDATA[CorSalud]]></abbrev-journal-title>
<issn>2078-7170</issn>
<publisher>
<publisher-name><![CDATA[Cardiocentro Ernesto Che Guevara]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2078-71702019000200167</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Disfunción sinusal transitoria secundaria a tratamiento con lacosamida]]></article-title>
<article-title xml:lang="en"><![CDATA[Transient sinus dysfunction secondary to lacosamide treatment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Grados Saso]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gracia Gutiérrez]]></surname>
<given-names><![CDATA[Anyuli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gracia Arguedas]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Toribio Velamazán]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[León Subías]]></surname>
<given-names><![CDATA[Erica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Huguet]]></surname>
<given-names><![CDATA[Claudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reinoso]]></surname>
<given-names><![CDATA[Rodolfo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz Montes]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Barbastro Servicio de Cardiología ]]></institution>
<addr-line><![CDATA[ Huesca]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Barbastro Servicio de Medicina Interna ]]></institution>
<addr-line><![CDATA[ Huesca]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital de Barbastro Servicio de Neurología ]]></institution>
<addr-line><![CDATA[ Huesca]]></addr-line>
<country>España</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital de Barbastro Servicio de Urgencias ]]></institution>
<addr-line><![CDATA[ Huesca]]></addr-line>
<country>España</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital de Barbastro Servicio de Neumología ]]></institution>
<addr-line><![CDATA[ Huesca]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>11</volume>
<numero>2</numero>
<fpage>167</fpage>
<lpage>170</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2078-71702019000200167&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2078-71702019000200167&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2078-71702019000200167&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Se presenta el caso de una paciente de 84 años de edad, con antecedentes de hipertensión arterial, dislipemia, insuficiencia venosa crónica y osteoartrosis, que -debido a una neuralgia del trigémino- había recibido tratamiento con varios fármacos, sin lograr control del dolor neuropático, por lo que se inició tratamiento con lacosamida en monoterapia, con incremento de dosis hasta lograr el objetivo terapéutico; pero la paciente presentó manifestaciones clínicas y alteraciones electrocardiográficas compatibles con disfunción sinusal, que se resolvieron tras la reducción de la dosis del fármaco.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The case of an 84-year-old female patient is presented, with a history of high blood pressure, dyslipidemia, chronic venous failure and osteoarthritis, which -due to trigeminal neuralgia- had received treatment with several drugs, without achieving neuropathic pain control; that was why the treatment with lacosamide was started in monotherapy, with an increase in dose until the therapeutic objective was achieved; but the patient presented clinical manifestations and electrocardiographic alterations compatible with sinus dysfunction, which were solved after reducing the dose of the drug.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ritmo cardíaco]]></kwd>
<kwd lng="es"><![CDATA[disfunción sinusal]]></kwd>
<kwd lng="es"><![CDATA[Anticonvulsivantes]]></kwd>
<kwd lng="es"><![CDATA[Lacosamida]]></kwd>
<kwd lng="es"><![CDATA[Efectos adversos]]></kwd>
<kwd lng="en"><![CDATA[Heart rhythm]]></kwd>
<kwd lng="en"><![CDATA[Sinus dysfunction]]></kwd>
<kwd lng="en"><![CDATA[Anticonvulsants]]></kwd>
<kwd lng="en"><![CDATA[Lacosamide]]></kwd>
<kwd lng="en"><![CDATA[Adverse effects]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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