<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2078-7170</journal-id>
<journal-title><![CDATA[CorSalud]]></journal-title>
<abbrev-journal-title><![CDATA[CorSalud]]></abbrev-journal-title>
<issn>2078-7170</issn>
<publisher>
<publisher-name><![CDATA[Cardiocentro Ernesto Che Guevara]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2078-71702019000300233</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Avances en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas. Parte 1 de 2: Morfogénesis cardíaca]]></article-title>
<article-title xml:lang="en"><![CDATA[Advances in the knowledge of the molecular and cellular bases of congenital heart diseases. Part 1 of 2: Cardiac morphogenesis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Taboada Lugo]]></surname>
<given-names><![CDATA[Noel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Gineco-Obstétrico Mariana Grajales Centro Provincial de Genética Médica ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>11</volume>
<numero>3</numero>
<fpage>233</fpage>
<lpage>240</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2078-71702019000300233&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2078-71702019000300233&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2078-71702019000300233&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Las cardiopatías congénitas son los defectos congénitos más frecuentes en humanos. Muchos estudios indican que el desarrollo cardíaco está estrechamente regulado por diferentes vías de señalización celular y eventos morfológicos, genéticamente controlados. La identificación de nuevos genes que intervienen en el proceso de cardiogénesis es de gran utilidad para conocer los mecanismos moleculares y celulares por el que se genera el amplio espectro fenotípico de las cardiopatías congénitas. Se realizó una revisión bibliográfica, con el objetivo de identificar los avances más recientes en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas; lo que permite una clasificación más efectiva de estos defectos congénitos y una futura optimización del tratamiento individualizado para cada paciente, además de ofrecer posibles puntos específicos y susceptibles de intervención que posibilitarían la prevención de algunos de los defectos congénitos más frecuentes en los seres humanos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTARACT Congenital heart diseases are the most common congenital defect in humans. Many studies indicate that the cardiac development is tightly regulated by different cell signaling pathways and genetically controlled morphological events. The identification of new genes involved in the cardiogenesis process is very useful in order to know the molecular and cellular mechanisms by which the broad phenotypic spectrum of congenital heart disease is generated. An updated bibliographic review was carried out, with the aim of identifying the most recent advances in the knowledge of the molecular and cellular bases of congenital heart disease. This knowledge allows a more effective classification of these congenital defects and a future optimization of the individualized treatment for each patient, in addition to offering possible specific and susceptible points of intervention that would allow the prevention of some of these more frequent congenital defects in humans.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cardiopatías congénitas]]></kwd>
<kwd lng="es"><![CDATA[Morfogénesis]]></kwd>
<kwd lng="es"><![CDATA[Polimorfismos de un simple nucleótido]]></kwd>
<kwd lng="es"><![CDATA[Factores de transcripción]]></kwd>
<kwd lng="es"><![CDATA[Metilación de ADN]]></kwd>
<kwd lng="es"><![CDATA[Vías de transducción de señales]]></kwd>
<kwd lng="en"><![CDATA[Congenital heart defects]]></kwd>
<kwd lng="en"><![CDATA[Morphogenesis]]></kwd>
<kwd lng="en"><![CDATA[Single nucleotide polymorphism]]></kwd>
<kwd lng="en"><![CDATA[Transcription factors]]></kwd>
<kwd lng="en"><![CDATA[DNA methylation]]></kwd>
<kwd lng="en"><![CDATA[Signal transduction]]></kwd>
</kwd-group>
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