<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2434</journal-id>
<journal-title><![CDATA[Revista Finlay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Finlay]]></abbrev-journal-title>
<issn>2221-2434</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos. Centro Provincial de información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24342019000100063</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de reacción por drogas con eosinofilia y síntomas sistémicos. Presentación de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Drug Reaction Syndrome with Eosinophilia and Systemic Symptoms. Case Presentation]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rangel Betarte]]></surname>
<given-names><![CDATA[Omar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta Fonseca]]></surname>
<given-names><![CDATA[Mileny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores Hernández]]></surname>
<given-names><![CDATA[Vanessa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Pediátrico Universitario Paquito González Cueto  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<volume>9</volume>
<numero>1</numero>
<fpage>63</fpage>
<lpage>68</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24342019000100063&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24342019000100063&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24342019000100063&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El síndrome de sensibilidad a drogas con eosinofilia y síntomas sistémicos es una reacción de hipersensibilidad que se desencadena por múltiples drogas, tales como antibióticos, antiinflamatorios, anticonvulsivantes que ocurre en el 2,2 % de los pacientes hospitalizados. Su importancia radica en la alta mortalidad, que puede alcanzar hasta un 30 %. Se presenta el caso de un niño de 5 años, con antecedentes de epilepsia diagnosticada, tratada con carbamazepina, que al corto tiempo de iniciar tratamiento anticonvulsivante evolucionó con fiebre de 11 días. Posteriormente aparecieron lesiones cutáneas eritematosas maculopapulares pruriginosas. Se ingresó con el diagnostico de síndrome febril prolongado. Los exámenes de laboratorio revelaron eosinofilia, elevación de pruebas hepáticas y de proteína C reactiva. Se planteó síndrome de sensibilidad a drogas inducido por carbamazepina, tras resultado de la biopsia de piel se suspende el anticomicial, remitiendo así el cuadro, con normalización de eosinófilos y función hepática. El paciente evolucionó sin fiebre y en buen estado general. Se presenta este caso por la baja prevalencia de este síndrome en el Hospital Pediátrico Universitario Paquito González Cueto de Cienfuegos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Drug reaction syndrome with eosinophilia and systemic symptoms is a reaction of hypersensitivity which triggers due to multiple drugs such as antibiotics, anti-inflammatory, anti-convulsants which occur in 2,2 % of admitted patients. Its importance is related in the high mortality that can achieve 30 %. A case of a 5 year old boy with antecedents of diagnosed epilepsy, treated with carbamazepine, who short time after starting the treatment had fever for 11 days. Posteriorly cutaneous erythematous pruritic maculopapular skin lesions appeared. He was admitted with the diagnosis of prolonged febrile syndrome. Laboratory test showed eosinophilia, elevation of liver tests and C-reactive protein. A syndrome of drug sensitivity was considered induced by carbamazepine, after the result of skin biopsy anti-comicial is suspended thus improving the condition, with normalization of eosinophils and liver function. The patient progressed without fever and good general condition. The case is presented due to the low prevalence of this syndrome in the University Pediatric Hospital Paquito González Cueto. Cienfuegos.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[síndrome de hipersensibilidad a medicamentos]]></kwd>
<kwd lng="es"><![CDATA[eosinofilia]]></kwd>
<kwd lng="es"><![CDATA[informes de casos.]]></kwd>
<kwd lng="en"><![CDATA[drug hypersensitivity syndrome]]></kwd>
<kwd lng="en"><![CDATA[eosinophilia]]></kwd>
<kwd lng="en"><![CDATA[cases reports.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[IC]]></given-names>
</name>
<name>
<surname><![CDATA[Sandín]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de DRESS por sulfonamidas]]></article-title>
<source><![CDATA[Med Cutan Iber Lat Am.]]></source>
<year>2006</year>
<volume>34</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>120-6</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quintero]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Flores]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de DRESS asociado con carbamazepina.]]></article-title>
<source><![CDATA[Bol Med Hosp Infant Mex.]]></source>
<year>2015</year>
<volume>72</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>118-23</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Álvaro]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Alvarado]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de sensibilidad a drogas con eosino&#64257;lia y síntomas sistémicos inducidos por fenitoína. Reporte de un caso.]]></article-title>
<source><![CDATA[Rev ANACEM]]></source>
<year>2015</year>
<volume>9</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>76-80</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Choudhary]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[McLeod]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Torchia]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Romanelli]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome]]></article-title>
<source><![CDATA[J Clin Aesthet Dermatol.]]></source>
<year>2013</year>
<volume>6</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>31-7</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Osuna]]></surname>
<given-names><![CDATA[OJ]]></given-names>
</name>
<name>
<surname><![CDATA[Toledo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Valencia]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ramírez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Mena]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reacción por drogas con eosino&#64257;lia: Síndrome DRESS, un gran simulador]]></article-title>
<source><![CDATA[Dermat Cosmet Méd Quir.]]></source>
<year>2013</year>
<volume>11</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>142-7</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Muciño]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz de León]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Briones]]></surname>
<given-names><![CDATA[CG]]></given-names>
</name>
<name>
<surname><![CDATA[Guerrero]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sandoval]]></surname>
<given-names><![CDATA[OI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de DRESS. Reporte de un caso clínico.]]></article-title>
<source><![CDATA[Rev Med Inst Mex Seguro Soc.]]></source>
<year>2013</year>
<volume>51</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>330-5</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Luque]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de DRESS. A propósito de un reporte de caso en el Hospital Militar Central.]]></article-title>
<source><![CDATA[Rev colom neuroc.]]></source>
<year>2015</year>
<volume>22</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>30-5</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramos]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome Dress: Presentación de un caso y actualización.]]></article-title>
<source><![CDATA[Rev argent dermatol]]></source>
<year>2013</year>
<volume>94</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1-10</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Filgueiras]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Guerreiro]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de DRESS.]]></article-title>
<source><![CDATA[Galícia Clin.]]></source>
<year>2011</year>
<volume>72</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>85-7</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wu Hsieh]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de Dress y síndrome de Steven Johnson.]]></article-title>
<source><![CDATA[Med leg Costa Rica]]></source>
<year>2011</year>
<volume>28</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>aprox. 5p</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bolte]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reacciones medicamentosas en la piel.]]></article-title>
<source><![CDATA[Rev Med Clin Condes]]></source>
<year>2011</year>
<volume>22</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>aprox. 10p</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ortíz]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Muñoz]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos en pediatría. Caso clínico.]]></article-title>
<source><![CDATA[Rev chil pediatr.]]></source>
<year>2017</year>
<volume>88</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>23-32</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Araujo]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Corriera]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Stevens-Johnson syndrome, toxic epidermal and erythema multiforme drug-related hospitalizations in a national administrative database.]]></article-title>
<source><![CDATA[Clin Transl Allergy.]]></source>
<year>2018</year>
<volume>8</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>83-95</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rabenkogo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Vigue]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Jeziorski]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Le syndrome DRESS: une toxidermieà connaître.]]></article-title>
<source><![CDATA[Arch Pediatr.]]></source>
<year>2015</year>
<volume>22</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>57-62</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahluwalia]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Abuabara]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Perman]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Yan]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human herpes virus 6 involvement in paediatric drug hypersensitivity syndrome.]]></article-title>
<source><![CDATA[Br J Dermatol.]]></source>
<year>2015</year>
<volume>172</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1090-5</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Husain]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Reddy]]></surname>
<given-names><![CDATA[BY]]></given-names>
</name>
<name>
<surname><![CDATA[Schwartz]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[DRESS syndrome: Part I. Clinical perspectives.]]></article-title>
<source><![CDATA[J Am Acad Dermatol.]]></source>
<year>2013</year>
<volume>68</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>693</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Teng]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Carbamazepine-induced DRESS syndrome in a child: Rapid response to pulsed corticosteroids.]]></article-title>
<source><![CDATA[Dermatol Online J.]]></source>
<year>2013</year>
<volume>19</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>181-70</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Funck]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Duong]]></surname>
<given-names><![CDATA[TA]]></given-names>
</name>
<name>
<surname><![CDATA[Bouvresse]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Bagot]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Wolkenstein]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Roujeau]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Therapeutic management of DRESS: A retrospective study of 38 cases.]]></article-title>
<source><![CDATA[J Am Acad Dermatol.]]></source>
<year>2015</year>
<volume>72</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>246-52</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
