<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2434</journal-id>
<journal-title><![CDATA[Revista Finlay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Finlay]]></abbrev-journal-title>
<issn>2221-2434</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos. Centro Provincial de información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24342021000100066</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación nutricional de pacientes en edad pediátrica con drepanocitosis tratados con hidroxiurea]]></article-title>
<article-title xml:lang="en"><![CDATA[Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with Hydroxyurea]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Jorge]]></surname>
<given-names><![CDATA[Belkis Lázara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morejón Díaz]]></surname>
<given-names><![CDATA[Lucía]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[León Rayas]]></surname>
<given-names><![CDATA[Yoandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santa Cruz]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Pediátrico Universitario Paquito González Cueto  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<volume>11</volume>
<numero>1</numero>
<fpage>66</fpage>
<lpage>73</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24342021000100066&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24342021000100066&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24342021000100066&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  estudios clínicos en pacientes con drepanocitosis han demostrado que el uso de hidroxiurea se asocia a una reducción de complicaciones agudas y crónicas, incluyendo las relacionadas con el estado nutricional de estos pacientes.  Objetivo: evaluar el estado nutricional en pacientes con drepanocitosis tratados con hidroxiurea en el Hospital Pediátrico Universitario Paquito González Cueto de Cienfuegos.  Métodos:  se realiza un estudio descriptivo, analítico y prospectivo de la totalidad de los pacientes con drepanocitosis tratados con hidroxiurea, atendidos en el Servicio de Hematología del Hospital Pediátrico de Cienfuegos en el periodo de enero 2012 a diciembre 2018. Las variables del estudio fueron: edad, sexo, variante de hemoglobina, manifestaciones clínicas y evaluación nutricional, parámetros hematológicos, hospitalizaciones y requerimientos transfusionales. La información se obtuvo de los expedientes clínicos.  Resultados:  se estudiaron 15 pacientes, hubo predomino del sexo femenino (60 %) y los adolescentes representaron el 80 % de los pacientes en estudio. Presentaban la forma homocigota 10 pacientes (66,7 %); la variante S&#946; talasemia y SC estuvo representada con 2 y 3 pacientes, respectivamente. No hubo diferencias significativas al comparar los valores hematológicos antes y después del tratamiento. Se observó una disminución en la frecuencia y gravedad de las crisis, en el número de hospitalizaciones y requerimientos transfusionales en la totalidad de los pacientes. La desnutrición estuvo presente en solo 4 pacientes del total.  Conclusiones:  el tratamiento con hidroxiurea para los pacientes en estudio resultó en mejoría clínica, reducción del número de ingresos y disminución de los requerimientos transfusionales, lo cual repercutió favorablemente en su estado nutricional.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTARCT  Background:  clinical studies in patients with sickle cell disease have shown that the use of hydroxyurea is associated with a reduction in acute and chronic complications, including those related to the nutritional status of these patients.  Objective:  to evaluate the nutritional status in patients with sickle cell disease treated with hydroxyurea at the Paquito González Cueto University Pediatric Hospital in Cienfuegos.  Methods:  a descriptive, analytical and prospective study was carried out of all the patients with sickle cell disease treated with hydroxyurea, treated at the Hematology Service of the Pediatric Hospital of Cienfuegos in the period from January 2012 to December 2018. The study variables were: age, sex, hemoglobin variant, clinical manifestations and nutritional evaluation, hematological parameters, hospitalizations and transfusion requirements. The information was obtained from the clinical records.  Results:  15 patients were studied, there was a predominance of females (60 %) and adolescents represented 80 % of the patients in the study. 10 patients (66.7 %) presented the homozygous form; the S&#946; thalassemia and SC variant were represented with 2 and 3 patients, respectively. There were no significant differences when comparing hematological values &#8203;&#8203;before and after treatment. A decrease was observed in the frequency and severity of the seizures, in the number of hospitalizations and transfusion requirements in all the patients. Malnutrition was present in only 4 patients out of the total.  Conclusions:  treatment with hydroxyurea for the study patients resulted in clinical improvement, reduction in the number of admissions and decrease in transfusion requirements, which favorably affected their nutritional status.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[estudios clínicos]]></kwd>
<kwd lng="es"><![CDATA[estado nutricional]]></kwd>
<kwd lng="es"><![CDATA[hidroxiurea, niños]]></kwd>
<kwd lng="en"><![CDATA[clinical studies]]></kwd>
<kwd lng="en"><![CDATA[nutritional status]]></kwd>
<kwd lng="en"><![CDATA[hydroxyurea]]></kwd>
<kwd lng="en"><![CDATA[child]]></kwd>
</kwd-group>
</article-meta>
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