<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2450</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Biol]]></abbrev-journal-title>
<issn>2221-2450</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24502021000200118</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Método de la membrana corioalantoidea del embrión de pollo: una alternativa en la experimentación toxicológica y farmacológica]]></article-title>
<article-title xml:lang="en"><![CDATA[Hen's egg test on chorioallantoic membrane: an alternative in the toxicological and pharmacological experimentation]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Stable-García]]></surname>
<given-names><![CDATA[Yanaysis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zamora-Rodriguez]]></surname>
<given-names><![CDATA[Zullyt]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-García]]></surname>
<given-names><![CDATA[Asela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas. Unidad de Productos Ozonizados Departamento de Estudios Biológicos]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas. Unidad de Productos Naturales Departamento de Farmacología experimenta]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>52</volume>
<numero>2</numero>
<fpage>118</fpage>
<lpage>128</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24502021000200118&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24502021000200118&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24502021000200118&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El método de la membrana corioalantoidea del embrión de pollo constituye un método alternativo para los ensayos toxicológicos y farmacológicos. La introducción de este ensayo supone una estrategia experimental para el desuso animal, dado que en Cuba se exige el cumplimiento de las regulaciones internacionales sobre la ética y la seguridad de los animales de laboratorio en los estudios farmacológicos y toxicológicos mediante los principios de Reemplazar, Reducir, Refinar. El objetivo de este trabajo de revisión es caracterizar el método de la membrana corioalantoidea del embrión de pollo, así como describir el método y las ventajas que aporta el ensayo como alternativa al uso de animales de experimentación. Para ello se recopiló toda la información publicada que se encontró disponible en la base de datos de PubMed. Se realizó una breve descripción enfocada en la estructura y en el método de la membrana corioalantoidea del embrión de pollo, así como de los ensayos toxicológicos y farmacológicos que utilizan dicha estructura. Además, se realizó un análisis en cuanto al alcance de los resultados del ensayo y acerca de las bases que propician la introducción del ensayo en los modelos experimentales. Este documento resume de forma organizada todos los resultados que aseguran y sustentan el beneficio de la introducción del método en los ensayos toxicológicos y farmacológicos. Se concluye que el método de la membrana corioalantoidea constituye una alternativa segura para los ensayos toxicológicos y farmacológicos y favorece la implementación de las &#8220;tres erres&#8221;.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Hen's egg test on chorioallantoic membrane is an alternative method for toxicological and pharmacological tests. The introduction of this test supposes an experimental strategy for animal disuse, since Cuba requires compliance with international regulations on ethics and safety of laboratory animals in pharmacological and toxic studies through the principles of Replace, Reduce, Refine. The objective of this review work is to characterize the hen's egg test on chorioallantoic membrane, as well as to describe method and the advantages that assay provides as an alternative to use of experimental animals. For this, all the published information that was available in the PubMed database was collected. A brief description was made focused on the structure and hen's egg test on chorioallantoic membrane, as well as the toxicological and pharmacological tests that use said structure. In addition, an analysis was carried out regarding the scope of the test results and about the bases that favor the introduction of the test in the experimental models. This document summarizes in an organized way all the results that ensure and support the benefit of the introduction of the method in toxicological and pharmacological tests. It is concluded that the chorioallantoic membrane method constitutes a safe alternative for toxicological and pharmacological tests and favors the implementation of the &#8220;three R's&#8221;.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[membrana corioalantoidea del embrión de pollo]]></kwd>
<kwd lng="es"><![CDATA[toxicología]]></kwd>
<kwd lng="es"><![CDATA[farmacología]]></kwd>
<kwd lng="en"><![CDATA[chorioallantoic membrane of chick embryo]]></kwd>
<kwd lng="en"><![CDATA[toxicology]]></kwd>
<kwd lng="en"><![CDATA[pharmacology]]></kwd>
</kwd-group>
</article-meta>
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