<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2450</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Biol]]></abbrev-journal-title>
<issn>2221-2450</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24502021000200187</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aspectos de farmacovigilancia: adulto mayor y susceptibilidad de reacciones adversas a medicamentos]]></article-title>
<article-title xml:lang="en"><![CDATA[Pharmacovigilance aspects: older adults and susceptibility to adverse drug reactions]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Stable-García]]></surname>
<given-names><![CDATA[Yanaysis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Atá]]></surname>
<given-names><![CDATA[Amelié]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuba-Venereo]]></surname>
<given-names><![CDATA[María de las M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcia Agustin]]></surname>
<given-names><![CDATA[Daysi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la Habana Instituto de Farmacia y Alimentos ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>52</volume>
<numero>2</numero>
<fpage>187</fpage>
<lpage>200</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24502021000200187&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24502021000200187&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24502021000200187&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Los adultos mayores constituyen un grupo poblacional vulnerable en presentar reacciones adversas a los medicamentos como consecuencia de la polimedicación consumida en esta población. En la práctica clínica existen varios factores que dificultan la detección de las reacciones adversas producidas por medicamentos. En este sentido, la farmacovigilancia es la actividad relacionada con la detección, evaluación, comprensión y prevención de los eventos adversos, de las reacciones adversas, de las sospechas de éstas, o de cualquier otro problema de seguridad relacionado con el uso de los medicamentos. Por lo tanto, el objetivo de este trabajo es realizar una breve descripción de las susceptibilidades de los adultos mayores en desarrollar reacciones adversas a los medicamentos. Para ello se recopilo toda la información publicada que se encontró disponible en la base de datos de PubMed. En tal sentido, se realizó una breve identificación de los cambios ocurridos en la adultez que conllevan a la presentación de reacciones adversas a medicamentos. Además, se describieron las reacciones adversas a los medicamentos y los sistemas de detección de reacciones adversas a medicamentos. Se concluye que en los adultos mayores ocurren cambios fisiológicos que inciden en el desarrollo de comorbilidades y en la necesidad de la polifarmacia, lo cual contribuye a la presencia de reacciones adversas a los medicamentos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Older adults constitute a vulnerable population group in presenting adverse reactions to medications as part of the polypharmacy consumed in this population. In clinical practice there are several factors that make it difficult to detect adverse drug-induced reactions. Pharmacovigilance is the activity related to the detection, evaluation, understanding and prevention of adverse events, adverse reactions or their suspicions, or any other safety problem related to the use of drugs. Therefore, the objective of this work is to make a description of the susceptibility of older adults to develop adverse reactions to medications. For this, all the published information that was available in the PubMed database was collected. In this sense, a brief identification was made of the changes that occurred in adulthood that lead to the presentation of adverse drug reactions. In addition, adverse drug reactions and adverse drug reaction detection systems were described. It is concluded that physiological changes occur in older adults that affect the development of comorbidities and the need for polypharmacy, which contributes to the presence of adverse drug reactions.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[adulto mayor]]></kwd>
<kwd lng="es"><![CDATA[reacciones adversas a medicamentos]]></kwd>
<kwd lng="es"><![CDATA[farmacovigilancia]]></kwd>
<kwd lng="en"><![CDATA[older adult]]></kwd>
<kwd lng="en"><![CDATA[adverse drug reactions]]></kwd>
<kwd lng="en"><![CDATA[pharmacovigilance]]></kwd>
</kwd-group>
</article-meta>
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