<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2450</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Biol]]></abbrev-journal-title>
<issn>2221-2450</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24502023000100023</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[PAPEL NEFROPROTECTOR DEL OZONO EN EL DAÑO RENAL CRÓNICO EXPERIMENTAL]]></article-title>
<article-title xml:lang="en"><![CDATA[NEPHROPROTECTIVE OZONE ROLE ON EXPERIMENTAL CHRONIC RENAL DAMAGE]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calunga Fernández]]></surname>
<given-names><![CDATA[José Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zamora Rodríguez]]></surname>
<given-names><![CDATA[Zullyt]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Menéndez Cepero]]></surname>
<given-names><![CDATA[Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Núñez Cairo]]></surname>
<given-names><![CDATA[Carlos Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Goberna Hernández]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Médico De La Salud Integral México-Cuba  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto de Ciencias Básicas y Preclínicas Victoria de Girón  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Docente Pediátrico: Eliseo Noel Camaño  ]]></institution>
<addr-line><![CDATA[ Matanzas]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>54</volume>
<fpage>23</fpage>
<lpage>29</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24502023000100023&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24502023000100023&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24502023000100023&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Los productos avanzados de la glicosilación de proteínas (PAGP) constituyen mediadores importantes que ocasionan daño al tejido renal en diferentes situaciones clínicas. Conociendo los efectos nefroprotectores de la ozonoterapia rectal (OTR), el objetivo del estudio fue demostrar la influencia de esta terapia en los niveles de fructosamina como PAGP y la actividad de la fosfolipasa A2 en tejido renal con insuficiencia renal crónica por ablación de la masa renal (AMR) en ratas. Se seleccionaron ratas Wistar hembra con peso corporal entre 200 y 220 g, se dividieron en cuatro grupos experimentales: un grupo control sin daño renal, otro grupo control con daño renal por AMR y otros dos grupos también con daño renal y tratados con ozonoterapia y oxígeno también por vía rectal, respectivamente. Los resultados evidenciaron la reducción significativa p&lt; 0,05 de los niveles de fructosamina y la actividad de la fosfolipasa A2 en el tejido renal de ratas tratadas con OTR. Por lo que se concluye que la OTR demostró acción antinflamatoria, como mecanismo contribuyente a la preservación de la estructura y función del riñón sometido a daño renal experimental crónico, por ablación de la masa renal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Advanced protein glycosylation products (APGP) represent an important mediators of renal tissue damage in different clinical situations. Knowing, the nephroprotective effects of rectal ozonetherapy (ROT), the objective of the study was to demostrate its influence on fructosemine levels and activity of phospholipase A2 in kidney tissue with chronic renal failure by renal mass ablation (RMA) in rats. Female Wistar rats with body weight between 200 and 220 g divided into four experimental groups were selected: a control group without renal damage, another control group with renal damage by RMA and two other groups also with renal damage and ozone therapy and oxygen also via the rectal route, respectively. The results evidenced the significant reduction p&lt; 0.05 of fructosamine levels and phospholipase A2 activity in the renal tissue of rats treated with OTR. Therefore, it is concluded that OTR demonstrated anti-inflammatory action, as a contributing mechanism to the preservation of structure and function kidney subjected to chronic experimental renal damage, by ablation of the renal mass.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Fructosamina]]></kwd>
<kwd lng="es"><![CDATA[ozonoterapia]]></kwd>
<kwd lng="es"><![CDATA[fosfolipasa A2]]></kwd>
<kwd lng="es"><![CDATA[productos avanzados de glicosilación de proteínas]]></kwd>
<kwd lng="es"><![CDATA[daño renal]]></kwd>
<kwd lng="en"><![CDATA[Fructosamine]]></kwd>
<kwd lng="en"><![CDATA[ozonetherapy]]></kwd>
<kwd lng="en"><![CDATA[phosfolipase A2]]></kwd>
<kwd lng="en"><![CDATA[Advanced protein glycosylation products]]></kwd>
<kwd lng="en"><![CDATA[Kidney damage]]></kwd>
</kwd-group>
</article-meta>
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