<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2450</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Biol]]></abbrev-journal-title>
<issn>2221-2450</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24502024000100030</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[BENEFICIOS DEL PREVENOX EN EL TRATAMIENTO DE AFECCIONES OSTEOMIOARTICULARES EN PERSONAS DE EDAD MEDIA Y AVANZADA]]></article-title>
<article-title xml:lang="en"><![CDATA[BENEFITS OF PREVENOX IN THE TREATMENT OF OSTEO-MYARTICULAR CONDITIONS IN MIDDLE AND OLD-AGED PEOPLE]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Núñez]]></surname>
<given-names><![CDATA[Yenney]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas. Biocubafarma  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>55</volume>
<fpage>30</fpage>
<lpage>38</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24502024000100030&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24502024000100030&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24502024000100030&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El envejecimiento poblacional es un fenómeno que ocurre en todos los países en mayor o menor grado, lo que provoca un incremento en el número y proporción de las personas ancianas. En Cuba esta proporción ha tenido un crecimiento progresivo, que sobrepasa el 18%, o sea, casi la quinta parte de los cubanos ya superan las seis décadas. Cada vez son más las investigaciones enfocadas al estudio de factores de riesgo, manifestaciones clínicas y enfermedades presentes en esta población; la osteoporosis, la osteoartritis, el climaterio y la menopausia, son algunos de ellas, y mucho más las investigaciones enfocadas al estudio de terapéuticas farmacológicas y no farmacológicas para prevenirlas o tratarlas, con el propósito de mejorar la calidad de vida de la población afectada. El Prevenox es una mezcla de ácidos primarios alifáticos de alto peso molecular obtenida de la cera de caña de azúcar, con efectos antioxidantes, hipolipemiantes, antiagregantes plaquetarios, y osteoprotectores, demostrados en estudios preclínicos y clínicos, además de resultar seguro y muy bien tolerado. El objetivo de esta revisión es abordar al Prevenox y sus efectos beneficiosos en la prevención o el tratamiento de afecciones osteomioarticulares frecuentes en personas de edad media y avanzada. Se expusieron, detallaron y analizaron las principales evidencias preclínicas y clínicas de los efectos del Prevenox sobre la osteoporosis y osteoartritis. Se concluye que el Prevenox constituye una alternativa para el manejo de afecciones osteomioarticulares en personas de edad media y avanzada, contribuyendo a mejorar la calidad de vida de las mismas para que puedan llegar a un envejecimiento más saludable.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Population aging is a phenomenon that occurs in all countries to a greater or lesser degree, which causes an increase in the number and proportion of elderly people. In Cuba this proportion has had a progressive growth, which exceeds 18%, that is, almost a fifth of Cubans are now over six decades old. More research is focused on the study of risk factors, clinical manifestations and diseases present in this population; osteoporosis, osteoarthritis, climacteric and menopause are some of them, and much more research focused on the study of pharmacological and non-pharmacological therapies to prevent or treat them, with the purpose of improving the quality of life of the affected population. Prevenox is a mixture of high molecular weight aliphatic primary acids obtained from sugar cane wax, with antioxidant, lipid-lowering, antiplatelet, and osteoprotective effects, demonstrated in preclinical and clinical studies, in addition to being safe and very well tolerated. The objective of this review is to address Prevenox and its beneficial effects in the prevention or treatment of common osteomyoarticular conditions in middle-aged and elderly people. The main preclinical and clinical evidence of the effects of Prevenox on osteoporosis and osteoarthritis were presented, detailed and analyzed. It´s concluded that Prevenox constitutes an alternative for the management of osteomyoarticular conditions in middle-aged and elderly people, contributing to improving their quality of life so that they can achieve healthier aging.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Prevenox]]></kwd>
<kwd lng="es"><![CDATA[edad media y avanzada]]></kwd>
<kwd lng="es"><![CDATA[postmenopausia]]></kwd>
<kwd lng="es"><![CDATA[osteoporosis]]></kwd>
<kwd lng="es"><![CDATA[osteoartritis]]></kwd>
<kwd lng="en"><![CDATA[Prevenox]]></kwd>
<kwd lng="en"><![CDATA[middle and advanced age]]></kwd>
<kwd lng="en"><![CDATA[postmenopause]]></kwd>
<kwd lng="en"><![CDATA[osteoporosis]]></kwd>
<kwd lng="en"><![CDATA[osteoarthritis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anria]]></surname>
<given-names><![CDATA[A.T.]]></given-names>
</name>
<name>
<surname><![CDATA[de Isaacs]]></surname>
<given-names><![CDATA[L.G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Revisión sistemática del concepto: envejecimiento saludable]]></article-title>
<source><![CDATA[Enfoque]]></source>
<year>2022</year>
<volume>31</volume>
<numero>27</numero>
<issue>27</issue>
<page-range>71-90</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arruzazabala]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Molina]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Carbajal]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Castaño]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[J. C. &amp;]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A randomised, double-blinded clinical study of the effects of D-003, a new substance purified from sugar cane wax, on platelet aggregation and plasma levels of arachidonic acid metabolites in healthy volunteers]]></article-title>
<source><![CDATA[Int J Pharmacoll Res]]></source>
<year>2004</year>
<volume>24</volume>
<numero>2-3</numero>
<issue>2-3</issue>
<page-range>55-63</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arruzazabala]]></surname>
<given-names><![CDATA[M. L]]></given-names>
</name>
<name>
<surname><![CDATA[Carbajal]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of D-003, a new compound purified from sugar cane wax, on platelet aggregation in healthy volunteers: A randomized, double-blinded clinical study]]></article-title>
<source><![CDATA[Clin Drug Invest]]></source>
<year>2002</year>
<volume>23</volume>
<page-range>107-18</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carbajal]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Arruzazabala]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Noa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Protective effect of D-003 on experimental spinal cord ischemia in rabbits]]></article-title>
<source><![CDATA[Prostagl, Leukotr &amp; Ess Fatty Acids]]></source>
<year>2004</year>
<volume>70</volume>
<page-range>1-6</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castaño]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Menéndez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Ledon]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[J. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzalez]]></surname>
<given-names><![CDATA[R. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Lescay]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of D-003: A new hypocholesterolaemic and antiplatelet compound on lipid profile and lipid peroxidation in healthy volunteers]]></article-title>
<source><![CDATA[Clin Drug Invest]]></source>
<year>2003</year>
<volume>23</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>193-203</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castaño]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Lescay]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of D-003 (5-40 mg/day) on lipid profile of patients with Type II hypercholesterolemia: a Phase II clinical study]]></article-title>
<source><![CDATA[Clin Drug Invest]]></source>
<year>2003</year>
<volume>23</volume>
<page-range>789-802</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Han]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Hamilton]]></surname>
<given-names><![CDATA[J. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Im]]></surname>
<given-names><![CDATA[H. J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Osteoarthritis: toward a comprehensive understanding of pathological mechanism]]></article-title>
<source><![CDATA[Bone Res]]></source>
<year>2017</year>
<volume>5</volume>
<page-range>16044-8</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ceballos]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Castaño]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Menéndez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[J. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Gámez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mesa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The effect of D-003 (10 mg/day) on biochemical paramaters of bone remodelling in postmenopausal women: a randomized double-blind study]]></article-title>
<source><![CDATA[Int J Clin Pharm Res]]></source>
<year>2005</year>
<volume>25</volume>
<page-range>175-86</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ceballos]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Castaño]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Mesa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gámez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Telles]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Marrero]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Jardines]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of D-003 (10 mg/day) on the bone mineral density of the lumbar spine and femoral neck in postmenopausal women: a randomized, double-blinded study]]></article-title>
<source><![CDATA[Korean J Intern Med]]></source>
<year>2011</year>
<volume>26</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>168-78</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ceballos]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Mesa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gámez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of D-003 (sugarcane wax acids) (10 mg/day) on the quality of life of postmenopausal women: a randomized, double-blinded study]]></article-title>
<source><![CDATA[IJPSRR]]></source>
<year>2015</year>
<volume>32</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>7-14</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fonseca]]></surname>
<given-names><![CDATA[G. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Manual de medicina de rehabilitación: calidad de vida más allá de la enfermedad]]></article-title>
<source><![CDATA[Editorial El Manual Moderno]]></source>
<year>2022</year>
<volume>6</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>32-54</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gámez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dose-dependent cholesterollowering effects of D-003 on normocholesterolemic rabbits]]></article-title>
<source><![CDATA[Curr Ther Res]]></source>
<year>2000</year>
<volume>61</volume>
<page-range>460-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gámez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Más]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Noa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute and subchronic oral toxicity of D-003 in rats]]></article-title>
<source><![CDATA[Toxicol Letters]]></source>
<year>2000</year>
<volume>118</volume>
<page-range>31-41</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Caracterización clínico-epidemiológica de la fragilidad en adultos mayores]]></article-title>
<source><![CDATA[Rev Medica Electrónica]]></source>
<year>2018</year>
<volume>40</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Riancho]]></surname>
<given-names><![CDATA[J. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Osteoporosis. Concepto. Epidemiología. Etiología. Manifestaciones clínicas y complicaciones]]></article-title>
<source><![CDATA[Medicine]]></source>
<year>2006</year>
<volume>9</volume>
<numero>60</numero>
<issue>60</issue>
<page-range>3873-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heredia]]></surname>
<given-names><![CDATA[N. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[E. S.]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[A. M. R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Beneficios de la actividad física para la promoción de un envejecimiento activo en personas mayores: revisión bibliográfica. Retos: nuevas tendencias en educación física, deporte y recreación]]></article-title>
<source><![CDATA[Revista de Psicología de la Educación]]></source>
<year>2021</year>
<volume>39</volume>
<page-range>829-34</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jordán]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Blanco]]></surname>
<given-names><![CDATA[M. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Saavedra]]></surname>
<given-names><![CDATA[L. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Valenzuela]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Valenzuela]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Osteoporosis, un problema de salud de estos tiempos]]></article-title>
<source><![CDATA[Revista Médica Electrónica]]></source>
<year>2021</year>
<volume>43</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>3192-201</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kloppenburg]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Berenbaum]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Osteoarthritis year in review 2019: epidemiology and therapy]]></article-title>
<source><![CDATA[Osteoarthritis and Cartilage]]></source>
<year>2020</year>
<volume>28</volume>
<page-range>242-8</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Más]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[D-003: A new substance with promising lipid modifying and pleiotropic effects for atherosclerosis management]]></article-title>
<source><![CDATA[Drugs of the Future]]></source>
<year>2004</year>
<volume>29</volume>
<page-range>773-86</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Noa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of D-003 (5-200 mg/ kg), a mixture of high molecular weight aliphatic acids from sugarcane wax, on bones and bone cell apoptosis in ovariectomized rats]]></article-title>
<source><![CDATA[Int J Tissue React]]></source>
<year>2005</year>
<volume>26</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>213-22</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Noa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Valle]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[D-003, a mixture of sugarcane wax acids, reduces joint damage in monosodium iodo acetate-induced osteoarthritis in rats]]></article-title>
<source><![CDATA[Int J Pharm Sci Rev Res]]></source>
<year>2012</year>
<volume>16</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>25-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Noa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Valle]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of D-003 on formaldehyde induced osteoarthritis in rats]]></article-title>
<source><![CDATA[Int J Pharm Sci Rev Res]]></source>
<year>2012</year>
<volume>16</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>21-4</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Menéndez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Amor]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Ledon]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[R.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodeiro]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Zayas]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Jimenez]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of rat lipoprotein lipid peroxidation by the oral administration of D-003, a mixture of very long chain saturated fatty acids]]></article-title>
<source><![CDATA[Can J Physiol Pharmacol]]></source>
<year>2002</year>
<volume>80</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>13-21</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Molina]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Arruzazabala]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Carbajal]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antithrombotic effects of D003]]></article-title>
<source><![CDATA[Pharmacol Res]]></source>
<year>2000</year>
<volume>42</volume>
<page-range>137-43</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Molina]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Arruzazabala]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Carbajal]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[D-003, a new compound with effects on arachidonic acid metabolites]]></article-title>
<source><![CDATA[Prostagl Leuktr Ess Fatty Acids]]></source>
<year>2002</year>
<volume>67</volume>
<page-range>19-24</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Molina]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Noa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Arruzazabala]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of D-003, a mixture of very long chain aliphatic acids purified from sugarcane wax, on cerebral ischemia in mongolian gerbils]]></article-title>
<source><![CDATA[J Med Food]]></source>
<year>2005</year>
<volume>8</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>482-7</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Noa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Valle]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of D-003 on lipopolysaccharides-induced osteonecrosis in rabbits]]></article-title>
<source><![CDATA[Indian J Pharm Sci]]></source>
<year>2011</year>
<volume>73</volume>
<page-range>537-42</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Mesa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Gámez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Jardines]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of D-003 (sugar cane alcohols) on the physical exercise on the static bicycle test]]></article-title>
<source><![CDATA[LAJP]]></source>
<year>2010</year>
<volume>29</volume>
<page-range>263-70</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Menéndez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[R. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of D-003, a mixture of high molecular weight acids from sugarcane wax, on lipid peroxidation (LP) markers of older individuals]]></article-title>
<source><![CDATA[Curr Ther Res]]></source>
<year>2008</year>
<volume>69</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>36-48</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Menéndez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[R. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of oral administration of D-003, product of the sugar cane wax on &#8220;in vivo&#8221; lipid peroxidation induced by oral administration of paracetamol in rats]]></article-title>
<source><![CDATA[Lat Am J Pharm]]></source>
<year>2007</year>
<volume>26</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>57-64</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Puente]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Carbajal]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Mesa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gámez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ameliorating effects of D-003, a mixture of sugarcane wax acids, on osteoarthritic symptoms]]></article-title>
<source><![CDATA[IJPSRR]]></source>
<year>2014</year>
<volume>28</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>11-9</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Puente]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Mas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Carbajal]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Ceballos]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Mesa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of the combined therapy with Abexol (beeswax alcohols) plus Prevenox (sugar cane wax acids), on osteoarthritis symptoms]]></article-title>
<source><![CDATA[Alternative Therapies in Health and Medicine]]></source>
<year>2016</year>
<volume>22</volume>
<page-range>15-23</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Puente]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Illnait]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Carbajal]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Más]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mesa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efectos del D-003 (10 mg/día) y los Ácidos Grasos Omega-3 sobre la calidad de vida en mujeres post-menopáusicas con riesgo de osteoporosis]]></article-title>
<source><![CDATA[Revista CENIC Ciencias Biológicas]]></source>
<year>2018</year>
<volume>49</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>018-27</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Polazzo]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk factors and burden of osteoarthritis]]></article-title>
<source><![CDATA[Annals of Physical and Rehabilitation Medicine]]></source>
<year>2016</year>
<volume>59</volume>
<page-range>134-8</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramírez]]></surname>
<given-names><![CDATA[K. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Espinosa]]></surname>
<given-names><![CDATA[D. F.]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[O. B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El envejecimento demográfico. ¿un problema o un triunfo de la vida sobre la muerte?]]></article-title>
<source><![CDATA[Didáctica y educación]]></source>
<year>2019</year>
<volume>10</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>17-34</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Robledo]]></surname>
<given-names><![CDATA[C. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Duque]]></surname>
<given-names><![CDATA[C. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[J. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[M. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Zapata]]></surname>
<given-names><![CDATA[R. B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Envejecimiento, calidad de vida y políticas públicas en torno al envejecimiento y la vejez]]></article-title>
<source><![CDATA[Revista CES Derecho]]></source>
<year>2022</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>132-60</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[M. D.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[J. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Alemán]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodeiro]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Arango]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Gámez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Goicochea]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Acosta]]></surname>
<given-names><![CDATA[C. P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of the Reproductive and Developmental Toxicity of the D-003, a Mixture of Long-chain Fatty Acids, in Rats and Rabbits]]></article-title>
<source><![CDATA[Fd Chem Toxicol]]></source>
<year>2004</year>
<volume>42</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1977-85</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rueda Hernández]]></surname>
<given-names><![CDATA[L.V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Esperanza de vida e inicio de la etapa de adulto mayor]]></article-title>
<source><![CDATA[Revista Salud Uninorte]]></source>
<year>2022</year>
<volume>38</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>112-24</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scanzello]]></surname>
<given-names><![CDATA[C. R. &amp;]]></given-names>
</name>
<name>
<surname><![CDATA[Moskowitz]]></surname>
<given-names><![CDATA[N. K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The post-NSAID era: what to use now for the pharmacologic treatment of pain and inflammation in osteoarthritis]]></article-title>
<source><![CDATA[Curr Rheumatol Rep]]></source>
<year>2008</year>
<volume>10</volume>
<page-range>49-56</page-range></nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shayo]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Asociación Argentina Para el Estudio de Climaterio]]></source>
<year>2019</year>
<page-range>4371-3169</page-range></nlm-citation>
</ref>
<ref id="B41">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sierra]]></surname>
<given-names><![CDATA[R. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[E. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Vicente]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Marrero]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[V. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estabilidad a largo plazo de lotes industriales de tabletas de Prevenox - 5 mg]]></article-title>
<source><![CDATA[Revista CENIC]]></source>
<year>2015</year>
<volume>46</volume>
<numero>^sSupl especial</numero>
<issue>^sSupl especial</issue>
<supplement>Supl especial</supplement>
</nlm-citation>
</ref>
<ref id="B42">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[A. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Climaterio y menopausia]]></article-title>
<source><![CDATA[Revista de la Facultad de Medicina]]></source>
<year>2018</year>
<volume>61</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>51-8</page-range><publisher-loc><![CDATA[México ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B43">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Valdés]]></surname>
<given-names><![CDATA[O. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Paulín]]></surname>
<given-names><![CDATA[Y. P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Calidad de vida del adulto mayor]]></article-title>
<source><![CDATA[Universidad Médica Pinareña]]></source>
<year>2019</year>
<volume>15</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>288-90</page-range></nlm-citation>
</ref>
<ref id="B44">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yedavally]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Ho]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Patalinghug]]></surname>
<given-names><![CDATA[E. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Update on Osteoporosis]]></article-title>
<source><![CDATA[Prim Care]]></source>
<year>2019</year>
<volume>46</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>175-90</page-range></nlm-citation>
</ref>
<ref id="B45">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yuniarwati]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Subijanto]]></surname>
<given-names><![CDATA[A. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Prasetyo]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determinants of Quality of Life among Patient with Knee Osteoarthritis]]></article-title>
<source><![CDATA[Journal of Epidemiology and Public Health]]></source>
<year>2019</year>
<volume>4</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>320-7</page-range></nlm-citation>
</ref>
<ref id="B46">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Moskowitz]]></surname>
<given-names><![CDATA[R.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Nuki]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Abramson]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Altman]]></surname>
<given-names><![CDATA[R. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Arden]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Bierma-Zeinstra]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Brandt]]></surname>
<given-names><![CDATA[K. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Croft]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Doherty]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Dougados]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hochberg]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hunter]]></surname>
<given-names><![CDATA[D. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Kwoh]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Lohmander]]></surname>
<given-names><![CDATA[L. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Tugwell]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[OARSI. Recommendations for the management of hip andknee osteoarthritis. Part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence]]></article-title>
<source><![CDATA[Osteoarthritis Cartilage]]></source>
<year>2007</year>
<volume>15</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>981-1000</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
