<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2224-5421</journal-id>
<journal-title><![CDATA[Revista Cubana de Química]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cub Quim]]></abbrev-journal-title>
<issn>2224-5421</issn>
<publisher>
<publisher-name><![CDATA[Ediciones UO, Universidad de Oriente]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2224-54212021000200113</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Desarrollo de un sistema de partículas poliméricas nanoestructuradas para la liberación controlada del 5-fluorouracilo]]></article-title>
<article-title xml:lang="en"><![CDATA[Development of nanostructured polymeric particles system to controlled release of 5-fluorouracil]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferrer-Viñals]]></surname>
<given-names><![CDATA[Denisse]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez-Brito]]></surname>
<given-names><![CDATA[Rubén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Baeza-Fonte]]></surname>
<given-names><![CDATA[Alen Nils]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de la Habana Instituto de Ciencia y Tecnología de Materiales ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la Habana Facultad de Química ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>33</volume>
<numero>2</numero>
<fpage>113</fpage>
<lpage>135</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2224-54212021000200113&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2224-54212021000200113&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2224-54212021000200113&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Este trabajo describe el proceso de preparación de partículas poliméricas submicrométricas de policianoacrilato de n-butilo cargado con 5-fluorouracilo, diseñado como un sistema de liberación controlada para tratar carcinomas en piel, capaz de mejorar el valor terapéutico de este citostático, superando así las desventajas de su uso en formulaciones que lo contienen libre. El monómero de partida fue sintetizado y caracterizado mediante técnicas espectroscópicas. Las partículas se obtuvieron mediante polimerización en emulsión y se caracterizaron por FT-IR, RMN-1H, RMN-13C y MALDI-TOF. El tamaño de partícula, morfología y características electrocinéticas fueron analizados mediante DLS, SEM y potencial zeta. Dos metodologías fueron empleadas para cargar las partículas con el citostático: adsorción superficial y absorción o encapsulación en la matriz polimérica. Los procesos de carga fueron monitoreados empleando UV o HPLC. Las nanoesferas resultaron estables y de diámetro menor a 500nm. La eficiencia de encapsulación del 5-Fluorouracilo fue de 30% para ambas metodologías.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT This work presents the steps towards the design of a new release system based on nanostructured particles of poly(butylcyanoacrylate) that were loaded with 5-Fluorouracyl. The monomer was previously synthesized and characterized by spectroscopic techniques. Then, polymeric particles were obtained by emulsion polymerization and characterized by FT-IR, RMN-1H, RMN-13C, MALDI-TOF while their size, morphology and electrokinetic characteristics were studied by SEM, DLS and zeta potential. Two drug loading mechanisms were studied: surface adsorption and absorption or entrapment in the polymeric network, the loading process of 5-Fluorouracyl to the nanostructured particles was followed by UV or HPLC. The nanospheres were stable and up to 500nm in size. 5-Fluorouracil loading studies showed an entrapment efficiency around 30% for both methodologies.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[policianoacrilato de n-butilo]]></kwd>
<kwd lng="es"><![CDATA[5-Fluorouracilo]]></kwd>
<kwd lng="es"><![CDATA[liberación controlada]]></kwd>
<kwd lng="es"><![CDATA[partículas poliméricas]]></kwd>
<kwd lng="en"><![CDATA[n-butylcyanoacrylate]]></kwd>
<kwd lng="en"><![CDATA[5-Fluorouracil]]></kwd>
<kwd lng="en"><![CDATA[controlled release]]></kwd>
<kwd lng="en"><![CDATA[polymeric particles]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[WAQAS]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[SHAIKH]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[NAWAS]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epidemiology and Risk Factors of Basal Cell Carcinoma]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[MIDGEN]]></surname>
<given-names><![CDATA[M. R.]]></given-names>
</name>
<name>
<surname><![CDATA[CHEN]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[SILAPUNT]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Basal Cell Carcinoma]]></source>
<year>2020</year>
<page-range>1-18</page-range><publisher-loc><![CDATA[Cham ]]></publisher-loc>
<publisher-name><![CDATA[Springer Nature]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[OLIVEIRA]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[5-Fluorouracil, innovative drug delivery systems to enhance bioavailability for topical use]]></article-title>
<source><![CDATA[Journal of Drug Delivery Science and Technology]]></source>
<year>2020</year>
<volume>61</volume>
<numero>102155</numero>
<issue>102155</issue>
<page-range>1-11</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[PATEL]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[DALWADI]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cytotoxicity and Cellular Uptake of 5-Fluorouracil Loaded Methylcellulose Nanohydrogel for Treatment of Oral Cancer]]></article-title>
<source><![CDATA[Letters in Applied NanoBioScience]]></source>
<year>2021</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1904-18</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MATUS-SANTOS]]></surname>
<given-names><![CDATA[J. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Revisión del monitoreo farmacocinético del 5-fluorouracilo como herramienta para incrementar eficacia y seguridad]]></article-title>
<source><![CDATA[Revista Médica del Instituto Mexicano del Seguro Social]]></source>
<year>2016</year>
<volume>54</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>354-62</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CALIENNI]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nano-formulation for topical treatment of precancerous lesions: skin penetration, in vitro, and in vivo toxicological evaluation]]></article-title>
<source><![CDATA[Drug Delivery and Translational Research]]></source>
<year>2018</year>
<volume>8</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>496-514</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MANSOORI]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hyaluronic acid&#8208;decorated liposomal nanoparticles for targeted delivery of 5&#8208;fluorouracil into HT&#8208;29 colorectal cancer cells]]></article-title>
<source><![CDATA[Journal of Cellular Physiology]]></source>
<year>2020</year>
<volume>235</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>6817-30</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[PELISSARI]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Potential of nanoparticles as drug delivery system for cancer treatment]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[INAMUDDIN]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
<name>
<surname><![CDATA[ASIRI]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Applications of Nanocomposite Materials in Drug Delivery]]></source>
<year>2018</year>
<page-range>431-68</page-range><publisher-loc><![CDATA[Oxford ]]></publisher-loc>
<publisher-name><![CDATA[Woodhead Publishing]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[VAUTHIER]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[LABARRE]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[PONCHEL]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Design aspects of poly (alkylcyanoacrylate) nanoparticles for drug delivery]]></article-title>
<source><![CDATA[Journal of Drug Targeting]]></source>
<year>2007</year>
<volume>15</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>641-63</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ARIAS]]></surname>
<given-names><![CDATA[J. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Study of carbonyl iron/poly (butylcyanoacrylate)(core/shell) particles as anticancer drug delivery systems: Loading and release properties]]></article-title>
<source><![CDATA[European Journal of Pharmaceutical Sciences]]></source>
<year>2008</year>
<volume>33</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>252-61</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[VAUTHIER]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Poly (alkylcyanoacrylates) as biodegradable materials for biomedical applications]]></article-title>
<source><![CDATA[Advanced Drug Delivery Reviews]]></source>
<year>2003</year>
<volume>55</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>519-48</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[GAO]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Polybutylcyanoacrylate nanocarriers as promising targeted drug delivery systems]]></article-title>
<source><![CDATA[Journal of Drug Targeting]]></source>
<year>2015</year>
<volume>23</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>481-96</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[KATTAN]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticles]]></article-title>
<source><![CDATA[Investigational New Drugs]]></source>
<year>1992</year>
<volume>10</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>191-9</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ESTANQUEIRO]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanotechnological carriers for cancer chemotherapy: the state of the art]]></article-title>
<source><![CDATA[Colloids and surfaces B: Biointerfaces]]></source>
<year>2015</year>
<volume>126</volume>
<page-range>631-48</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[OJHA]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanotechnology: Introduction and Basic Concepts]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[KUMAR]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[JAIN]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<source><![CDATA[Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives]]></source>
<year>2021</year>
<page-range>1-19</page-range><publisher-loc><![CDATA[Boca Raton ]]></publisher-loc>
<publisher-name><![CDATA[CRC Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CHENG]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Design of self-polymerized insulin loaded poly(n-butylcyanoacrylate) nanoparticles for tunable oral delivery]]></article-title>
<source><![CDATA[Journal of Controlled Release]]></source>
<year>2020</year>
<volume>321</volume>
<page-range>641-53</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ARIAS]]></surname>
<given-names><![CDATA[J. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Magnetite/poly (alkylcyanoacrylate)(core/shell) nanoparticles as 5-Fluorouracil delivery systems for active targeting]]></article-title>
<source><![CDATA[European Journal of Pharmaceutics and Biopharmaceutics]]></source>
<year>2008</year>
<volume>69</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>54-63</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[AHLIN]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Investigation of polymeric nanoparticles as carriers of enalaprilat for oral administration]]></article-title>
<source><![CDATA[International Journal of Pharmaceutics]]></source>
<year>2002</year>
<volume>239</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<page-range>113-20</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[BENNET]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[KIM]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Polymer Nanoparticles for Smart Drug Delivery]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[SEZER]]></surname>
<given-names><![CDATA[A. D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Application of Nanotechnology in Drug Delivery]]></source>
<year>2014</year>
<page-range>257-310</page-range><publisher-loc><![CDATA[Rijeka ]]></publisher-loc>
<publisher-name><![CDATA[InTech]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ARIAS]]></surname>
<given-names><![CDATA[J. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Poly (alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery: a comparative study]]></article-title>
<source><![CDATA[Colloids and Surfaces B: Biointerfaces]]></source>
<year>2008</year>
<volume>62</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>64-70</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ARSALAN]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Surface-modified polymeric nanoparticles for drug delivery to cancer cells]]></article-title>
<source><![CDATA[Expert Opinion on Drug Delivery]]></source>
<year>2021</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-24</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[GRAF]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[McDOWELL]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[RADES]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Poly (alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics-is there real potential?]]></article-title>
<source><![CDATA[Expert Opinion on Drug Delivery]]></source>
<year>2009</year>
<volume>6</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>371-87</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
