<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2224-5421</journal-id>
<journal-title><![CDATA[Revista Cubana de Química]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cub Quim]]></abbrev-journal-title>
<issn>2224-5421</issn>
<publisher>
<publisher-name><![CDATA[Ediciones UO, Universidad de Oriente]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2224-54212023000100088</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación antimicrobiana del extracto acuoso de la biomasa de la microalga Phorphyridium cruentum]]></article-title>
<article-title xml:lang="en"><![CDATA[Antimicrobial evaluation of the aqueous extract of the biomass of the microalga Phorphyridium cruentum]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferrer-Salas]]></surname>
<given-names><![CDATA[Dagmara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Llauradó-Maury]]></surname>
<given-names><![CDATA[Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Duharte]]></surname>
<given-names><![CDATA[George]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lebeque-Pérez]]></surname>
<given-names><![CDATA[Yamila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Oriente Facultad de Ingeniería Química y Agronomía Departamento de Fundamentos Químicos y Biológicos]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Oriente Facultad de Ciencias Naturales Departamento de Farmacia]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Laboratorio de Anticuerpos Monoclonales  ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Oriente Centro de Estudios de Biotecnología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<volume>35</volume>
<numero>1</numero>
<fpage>88</fpage>
<lpage>104</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2224-54212023000100088&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2224-54212023000100088&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2224-54212023000100088&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Actualmente, existe una creciente preocupación por el aumento de la resistencia microbiana de numerosos agentes patógenos. Las microalgas han demostrado tener múltiples aplicaciones en la industria biotecnológica. Porphyridium cruentum es una microalga que exhibe un amplio contenido de polisacáridos y proteínas con potencial actividad farmacológica. Este trabajo evalúa la actividad antimicrobiana de la biomasa P. cruentum frente a los parásitos Leishmania infantum, Trypanosoma rhodesiense, Trypanosoma cruzi, y Trypanosoma brucei a través del método de microdilución en placas, así como la citotoxicidad en líneas celulares de leucocitos, utilizando como fármaco de referencia el Tamoxifeno. La biomasa mostró actividad inhibitoria frente a los parásitos T. brucei, T. rhodesiensis, y T. cruzi. El estudio demostró, además, que la biomasa no ejerce actividad citotóxica sobre monocitos humanos THP-1 y macrófagos murinos RAW 264.7. Los resultados obtenidos apuntan que los compuestos activos presentes en Porphyridium cruentum podrían ser considerados como posibles candidatos antimicrobianos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Microalgae have proven to have multiple applications in the biotechnology industry. Porphyridium cruentum is a microalgae that exhibits a wide content of polysaccharides and proteins with potential pharmacological activity. This work evaluates the antimicrobial activity of the P. cruentum biomass against the parasites Leishmania infantum, Trypanosoma rhodesiense, Trypanosoma cruzi, and Trypanosoma brucei through the microdilution method in plates, as well as the cytotoxicity in leukocyte cell lines, using as a drug reference Tamoxifen. The biomass showed inhibitory activity against the parasites T. brucei, T. rhodesiensis, and T. cruzi. The study also demonstrated that the biomass does not exert cytotoxic activity on THP-1 human monocytes and RAW 264.7 murine macrophages. The results obtained indicate that the active compounds present in Porphyridium cruentum could be considered as possible antimicrobial candidates.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Phorphyridium cruentum]]></kwd>
<kwd lng="es"><![CDATA[actividad antimicrobiana]]></kwd>
<kwd lng="es"><![CDATA[actividad citotóxica]]></kwd>
<kwd lng="es"><![CDATA[líneas tumorales.]]></kwd>
<kwd lng="en"><![CDATA[Phorphyridium cruentum]]></kwd>
<kwd lng="en"><![CDATA[antimicrobial activity]]></kwd>
<kwd lng="en"><![CDATA[cytotoxic activity]]></kwd>
<kwd lng="en"><![CDATA[tumor lines.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[OLMEDO-GALARZA]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Carbohydrates and proteins in microalgaes: potential functional foods]]></article-title>
<source><![CDATA[Brazilian Journal of Food Technology.]]></source>
<year>2019</year>
<volume>22</volume>
<page-range>1981-6723</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[KHAN]]></surname>
<given-names><![CDATA[M. I.]]></given-names>
</name>
<name>
<surname><![CDATA[SHIN]]></surname>
<given-names><![CDATA[J. H.]]></given-names>
</name>
<name>
<surname><![CDATA[KIM]]></surname>
<given-names><![CDATA[J. D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The promising future of microalgae: current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products]]></article-title>
<source><![CDATA[Microbial cell factories]]></source>
<year>2018</year>
<volume>17</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-21</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[DHANYA- SWATI]]></surname>
<given-names><![CDATA[K. I]]></given-names>
</name>
<name>
<surname><![CDATA[VANKA]]></surname>
<given-names><![CDATA[V. I.]]></given-names>
</name>
<name>
<surname><![CDATA[OSBORNE]]></surname>
<given-names><![CDATA[W. J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial activity of Ulvareticulata and its endophytes]]></article-title>
<source><![CDATA[Journal of Ocean University of China]]></source>
<year>2016</year>
<volume>15</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>363-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[FALAISE]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial Compounds from Eukaryotic Microalgae against Human Pathogens and Diseases in Aquaculture]]></article-title>
<source><![CDATA[Marine Drugs]]></source>
<year>2016</year>
<volume>14</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1660-3397</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[HAMIDI]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications]]></article-title>
<source><![CDATA[Marine Drugs]]></source>
<year>2019</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>28</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[HUSSEIN]]></surname>
<given-names><![CDATA[H. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phytochemical screening, metabolite profiling and enhanced antimicrobial activities of microalgal crude extracts in co-application with silver nanoparticle]]></article-title>
<source><![CDATA[Bioresources and Bioprocessing]]></source>
<year>2020</year>
<volume>7</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-17</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[SATHASIVAM]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[RADHAKRISHNAN]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[HASHEM]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[ABD ALLAH]]></surname>
<given-names><![CDATA[E. F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Microalgae metabolites: A rich source for food and medicine]]></article-title>
<source><![CDATA[Saudi Journal of Biological Sciences]]></source>
<year>2019</year>
<volume>26</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>709-22</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[VERDUGO-GONZÁLEZ]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial potential of a hydrolyzed protein extract of the microalgae Nannochloropsissp.]]></article-title>
<source><![CDATA[DYNA]]></source>
<year>2019</year>
<volume>86</volume>
<numero>211</numero>
<issue>211</issue>
<page-range>192-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CANO-EUROPA]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Uso terapéutico de algunos microorganismos, microalgas, algas y hongos]]></article-title>
<source><![CDATA[Revista Mexicana de Ciencias Farmacéuticas.]]></source>
<year>2012</year>
<volume>43</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>22-30</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[VENKATESAN]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibacterial activity of the marine diatom, Rhizosolenia alata (Brightwell, 1858) against human pathogens]]></article-title>
<source><![CDATA[Research Journal of Microbiology]]></source>
<year>2007</year>
<volume>2</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>98-100</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ABED]]></surname>
<given-names><![CDATA[R. M. M.]]></given-names>
</name>
<name>
<surname><![CDATA[DOBRETSOV]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[SUDESH]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Applications of cyanobacteria in Biotechnology]]></article-title>
<source><![CDATA[Journal of Applied Microbiology]]></source>
<year>2009</year>
<volume>106</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-12</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[GONZÁLEZ-MENDOZA]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[MAGUIÑA-VARGAS]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[GONZÁLEZ-PONCE]]></surname>
<given-names><![CDATA[F. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[La resistencia a los antibióticos: un problema muy serio]]></article-title>
<source><![CDATA[Acta Med. Peru]]></source>
<year>2019</year>
<volume>36</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>145-51</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ERBIL]]></surname>
<given-names><![CDATA[G Ç.]]></given-names>
</name>
<name>
<surname><![CDATA[ELP]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[DURMAZ]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phycoerythrin Accumulation of Porphyridium cruentum Culture at Indoor Tubular Photobioreactor]]></article-title>
<source><![CDATA[University Journal of Agricultural Sciences.]]></source>
<year>2022</year>
<volume>32</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>81-8</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[BENAVIDES]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[RITO-PALOMARES]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Simplified two-stage method to B-phycoerythrin recovery from Porphyridium cruentum]]></article-title>
<source><![CDATA[Journal of Chromatography B.]]></source>
<year>2006</year>
<volume>844</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>39-44</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[NIIZAWA]]></surname>
<given-names><![CDATA[Ignacio.]]></given-names>
</name>
</person-group>
<source><![CDATA[Diseño, modelado y optimización de foto-biorreactores destinados al cultivo de microalgas para diferentes aplicaciones tecnológicas]]></source>
<year>2015</year>
<publisher-loc><![CDATA[Argentina ]]></publisher-loc>
<publisher-name><![CDATA[Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[BENAVIDES]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[RITO-PALOMARES]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bioprocess intensification: A potential aqueous two-phase process for the primary recovery of B-phycoerythrin from Porphyridium cruentum.]]></article-title>
<source><![CDATA[J. Chromatogr. B.]]></source>
<year>2004</year>
<volume>807</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>33-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[GABRIELSON]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of redox indicators and the use of digital scanners and spectrophotometer for quantification of microbial growth in microplates]]></article-title>
<source><![CDATA[J. Microbiol Methods]]></source>
<year>2002</year>
<volume>50</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>63-73</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CHATELAIN]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chagas Disease Drug Discovery: Toward a New Era]]></article-title>
<source><![CDATA[Journal of Biomolecular Screening.]]></source>
<year>2015</year>
<volume>20</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>22-35</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CERVANTES-URIETA]]></surname>
<given-names><![CDATA[V. A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cultivo y composición bioquímica de diatomeas marinas (Bacillariophyta) de la Bahía de Santa Lucía, Acapulco, México]]></article-title>
<source><![CDATA[Gayana. Botánica]]></source>
<year>2020</year>
<volume>77</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>11-22</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[HERNÁNDEZ-MIRELES]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[RITO-PALOMARES]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Improved recovery of B- phycoerythrin produced by the red microalga Porphyridium cruentum]]></article-title>
<source><![CDATA[Journal of 42 Chemical Technology &amp; Biotechnology: International Research in Process, Environmental &amp; Clean Technology]]></source>
<year>2006</year>
<volume>81</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>989-96</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[RITO-PALOMARES]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[NÚNEZ]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[AMADOR]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aplicación práctica de sistemas bifásicos. Elementos para el desarrollo de un proceso prototipo para la recuperación de ficocianina Espirulina máxima]]></article-title>
<source><![CDATA[J. Chem Tecnología Biotecnología.]]></source>
<year>2001</year>
<volume>76</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1273-80</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CASTRO-PIÑOL]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular docking of the interaction of 4, 5 - phenyl and 4, 5 - furyl imidazoles with T. Cruci, T. Brucei and L. Infantum C y p 51 enzymes]]></article-title>
<source><![CDATA[Rev. Cubana Quím]]></source>
<year>2022</year>
<volume>34</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>159-79</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[HEMLATA]]></surname>
<given-names><![CDATA[SUMBUL A.]]></given-names>
</name>
<name>
<surname><![CDATA[TASNEEM]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Extraction, purification and characterization of phycoerythrin from Michrochate and its biological activities]]></article-title>
<source><![CDATA[Biocatalysis and Agricultural Biotechnology.]]></source>
<year>2018</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>84-9</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[GÓMEZ-LUNA]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efecto de diferentes protocolos de aplicación de un campo magnético (0.03T) sobre el crecimiento, viabilidad y composición pigmentaria de Haematococcuspluvialis Flotow en suficiencia y ausencia de nitrógeno]]></article-title>
<source><![CDATA[Biotecnología Vegetal]]></source>
<year>2009</year>
<volume>9</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>105-17</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[GUZMÁN-MURILLO]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[ASCENCIO]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiadhesive activity of sulphathed exopolisaccharides of microalgae on attachmente of red sore disease associated bacteria and Heliobacter pylori to tissue culture cells]]></article-title>
<source><![CDATA[Applied Micobiology.]]></source>
<year>2000</year>
<volume>12</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>273-476</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[SÁNCHEZ-SAAVEDRA]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[LICEA-NAVARRO]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[BERNÁLDEZ-SARABIA]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of the antibacterial activity of different species of phytoplankton]]></article-title>
<source><![CDATA[Revista de Biología Marina y Oceanografí]]></source>
<year>2010</year>
<volume>45</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>531-6</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MORAES de]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pinto, Phytol, a diterpene alcohol from chlorophyll, as a drug against neglected tropical disease Schistosomiasis mansoni, PLoS Negl]]></article-title>
<source><![CDATA[Trop. Dis]]></source>
<year>2014</year>
<volume>8</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[AllMENDINGER]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae]]></article-title>
<source><![CDATA[Phytother. Res]]></source>
<year>2010</year>
<volume>24</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1099-103</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CHATELAIN]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chagas disease drug Discovery]]></article-title>
<source><![CDATA[J. Biomol. Screen]]></source>
<year>2015</year>
<volume>20</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>22-35</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MONTIEL]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[DÍAZ]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Respuesta inmune de las células del hospedero a la infección por Trypanosoma cruzi]]></article-title>
<source><![CDATA[Revista Médica del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera. Costa Rica]]></source>
<year>2002</year>
<numero>1</numero>
<issue>1</issue>
<page-range>57-63</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
