<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2224-5421</journal-id>
<journal-title><![CDATA[Revista Cubana de Química]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cub Quim]]></abbrev-journal-title>
<issn>2224-5421</issn>
<publisher>
<publisher-name><![CDATA[Ediciones UO, Universidad de Oriente]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2224-54212023000200200</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estudio de liberación de 5-fluorouracilo desde nanopartículas de policianoacrilato de n-butilo]]></article-title>
<article-title xml:lang="en"><![CDATA[Release study of 5-fluorouracil from poly (butylcyanoacrylate) nanoparticles]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferrer-Viñals]]></surname>
<given-names><![CDATA[Denisse]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez-Brito]]></surname>
<given-names><![CDATA[Rubén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Baeza-Fonte]]></surname>
<given-names><![CDATA[Alen Nils]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de La Habana Instituto de Ciencia y Tecnología de Materiales ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de La Habana Facultad de Química ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<volume>35</volume>
<numero>2</numero>
<fpage>200</fpage>
<lpage>214</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2224-54212023000200200&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2224-54212023000200200&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2224-54212023000200200&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El 5-fluorouracilo (5-FU) es un citostático comúnmente empleado en el tratamiento del cáncer. Hoy en día, se busca potenciar su uso farmacológico tratando de reducir los efectos adversos. En esta investigación se estudia la liberación de 5-FU, adsorbido y encapsulado, para su posterior uso como sistema de liberación controlada desde un sistema de nanopartículas de policianoacrilato de n-butilo. Las partículas encapsuladas se obtuvieron por el método de polimerización en emulsión, en presencia de 5-FU en el medio, mientras las adsorbidas lo fueron mediante contacto de las partículas poliméricas con el 5-FU en disolución. El proceso de adsorción pudo ser descrito adecuadamente por los modelos de Langmuir. El porcentaje liberado de 5-FU encapsulado (61,4 %) resultó mayor que el de adsorbido (7,7 %), resultando el primero, más idóneo. Los experimentos preliminares de ambos procesos demostraron que cumplen con un modelo cinético de orden cero.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT 5-Fluorouracil (5-FU) is a cytostatic commonly used in cancer treatment. Today, it seeks to enhance its pharmacological use trying to reduce adverse effects. This research studies the release of 5-FU from an adsorbed and encapsulated poly (butylcyanoacrylate) nanoparticles system for its subsequent use as a controlled release system. The encapsulated particles were obtained by the emulsion polymerization method, in the presence of 5-FU in the medium, while those adsorbed were obtained by contact of the polymeric particles with the 5-FU in solution. The adsorption process could be adequately described by the Langmuir. Preliminary release experiments showed that a zero-order kinetic model is fulfilled for both processes, where the released percentage of encapsulated 5-FU is greater (61,4 %) than that of adsorbed (7,7 %).]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[5-fluorouracilo]]></kwd>
<kwd lng="es"><![CDATA[liberación controlada]]></kwd>
<kwd lng="es"><![CDATA[nanopartículas]]></kwd>
<kwd lng="es"><![CDATA[policianoacrilato de n-butilo.]]></kwd>
<kwd lng="en"><![CDATA[5-fluorouracil]]></kwd>
<kwd lng="en"><![CDATA[controlled release]]></kwd>
<kwd lng="en"><![CDATA[nanoparticles]]></kwd>
<kwd lng="en"><![CDATA[poly (butylcyanoacrylate).]]></kwd>
</kwd-group>
</article-meta>
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