<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2304-0106</journal-id>
<journal-title><![CDATA[Anales de la Academia de Ciencias de Cuba]]></journal-title>
<abbrev-journal-title><![CDATA[Anales de la ACC]]></abbrev-journal-title>
<issn>2304-0106</issn>
<publisher>
<publisher-name><![CDATA[Academia de Ciencias de Cuba]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2304-01062021000300011</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Quitosana y sus sales: producción nacional, caracterización y aplicaciones farmacéuticas]]></article-title>
<article-title xml:lang="en"><![CDATA[Chitosan and its salts: national production, characterization and pharmaceutical applications]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-Viaña]]></surname>
<given-names><![CDATA[Nilia de la Paz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Cervera]]></surname>
<given-names><![CDATA[Mirna]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Peña]]></surname>
<given-names><![CDATA[Caridad Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Ricardo]]></surname>
<given-names><![CDATA[Dania]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nogueira Mendoza]]></surname>
<given-names><![CDATA[Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montes de Oca Porto]]></surname>
<given-names><![CDATA[Yanet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Espinosa]]></surname>
<given-names><![CDATA[Vivian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bellma Menéndez]]></surname>
<given-names><![CDATA[Addis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palazón López]]></surname>
<given-names><![CDATA[Zoe Catalina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Investigación y Desarrollo de Medicamentos (CIDEM)  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de La Habana Instituto de Farmacia y Alimentos (IFAL) ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>11</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2304-01062021000300011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2304-01062021000300011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2304-01062021000300011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Los exoesqueletos de crustáceos constituyen fuentes de obtención de biopolímeros de gran versatilidad, y desechos sólidos que contaminan el medio ambiente. Objetivos: establecer procesos tecnológicos a escala industrial para la obtención de quitosana y sus sales, para aplicaciones biomédicas.  Métodos:  Una temperatura de mezcla de 80 °C y de reacción de 100 °C/15 minutos dobles, fueron las mejores condiciones para la obtención de la quitosana. Por el método de secado por aspersión se obtuvieron las sales de quitosana, estableciéndose, una temperatura de entrada de 160 °C ± 5 °C y de salida de 100 °C ± 5 °C, a partir de una disolución de quitosana en ácido acético o láctico.  Resultados:  La caracterización confirmó la obtención de quitosana con un grado de desacetilación superior al 70 % y una masa molecular media de 310 000 g/mol; así como la formación de las sales del biopolímero solubles en agua. Se demostró la homogeneidad de las propiedades de los productos en los lotes escalados y la reproducibilidad de los procesos tecnológicos establecidos, en las condiciones de la industria nacional. Se comprobó la estabilidad física, química y microbiológica del biopolímero y sus sales, durante 24 meses. Se evaluó su capacidad emulgente lográndose la estabilización de sistemas semisólidos. Las bases emulsionadas e hidrosolubles acuosas, empleando quitosana y acetato de quitosana, mostraron adecuada estabilidad física sin interferencias en la liberación del fármaco modelo, quedando demostrada su aplicación como agentes estabilizantes. Conclusiones: se obtuvieron tres nuevas materias primas de producción nacional a escala industrial con calidad, para ser empleadas en la industria farmacéutica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: The exoskeletons of crustaceans are sources of highly versatile biopolymers and solid wastes that pollute the environment. Objectives: Establish technological processes on an industrial scale to obtain chitosan and its salts, for biomedical applications.  Methods: A mixing temperature of 80 ° C and a reaction temperature of 100 °C/15 double minutes were the best conditions for obtaining chitosan. Chitosan salts were obtained by the spray drying method, establishing an inlet temperature of 160 °C ± 5 °C and an outlet temperature of 100 °C ± 5 °C, from a solution of chitosan in acetic or lactic acid.  Results: The characterization confirmed the obtaining of chitosan with a degree of deacetylation greater than 70 % and an average molecular mass of 310,000 g/mol; as well as the formation of the salts of the biopolymer soluble in water. The homogeneity of the properties of the products in the scaled batches and the reproducibility of the established technological processes, under the conditions of the national industry, were demonstrated. The physical, chemical and microbiological stability of the biopolymer and its salts was verified for 24 months. Its emulsifying capacity was evaluated, achieving the stabilization of semisolid systems. The emulsified and water-soluble bases, using chitosan and chitosan acetate, showed adequate physical stability without interference in the release of the model drug, their application as stabilizing agents being demonstrated. Conclusions: three new raw materials of national production were obtained on an industrial scale with quality, to be used in the pharmaceutical industry.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[quitosana]]></kwd>
<kwd lng="es"><![CDATA[sales de quitosana]]></kwd>
<kwd lng="es"><![CDATA[secado por aspersión]]></kwd>
<kwd lng="es"><![CDATA[emulsiones]]></kwd>
<kwd lng="es"><![CDATA[liberación]]></kwd>
<kwd lng="en"><![CDATA[chitosan]]></kwd>
<kwd lng="en"><![CDATA[chitosan salts]]></kwd>
<kwd lng="en"><![CDATA[spray drying]]></kwd>
<kwd lng="en"><![CDATA[emulsions]]></kwd>
<kwd lng="en"><![CDATA[release]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pintueles]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
<name>
<surname><![CDATA[Alzugaray]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Puga]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Morales]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluación de la pesquería de langosta Panulirus argus (Decapoda Palinuridae) en la plataforma noroccidental]]></article-title>
<source><![CDATA[Revista Cubana de Investigaciones Pesqueras]]></source>
<year>2016</year>
<volume>33</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>24-9</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ifuku]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chitin and chitosan nanofibers Preparation and chemical modifications]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2014</year>
<volume>19</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>18367-80</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Peniche]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Estudios sobre Quitina y Quitosana]]></source>
<year>2006</year>
<publisher-name><![CDATA[Facultad de Química, Universidad de La Habana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hidalgo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Nieto]]></surname>
<given-names><![CDATA[OM]]></given-names>
</name>
<name>
<surname><![CDATA[Paneque]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[LLópiz]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estudio de quitosanos cubanos derivados de la quitina de la langosta]]></article-title>
<source><![CDATA[Rev Iberoam Polím]]></source>
<year>2009</year>
<volume>10</volume>
<page-range>11-27</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mohammed]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Syeda]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wasan]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Wasan]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An overview of chitosan nanoparticles and its application in non-parenteral drug delivery]]></article-title>
<source><![CDATA[Pharmaceutics]]></source>
<year>2017</year>
<volume>9</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>53</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saporito]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sandri]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Rossi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Bonferoni]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Riva]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Malavasi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Freeze dried chitosan acetate dressings with glycosaminoglycans and traxenamic acid]]></article-title>
<source><![CDATA[Carbohydrate Polymers]]></source>
<year>2018</year>
<volume>184</volume>
<page-range>408-17</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de la Paz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[OD]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Optimización del proceso de obtención de quitosana derivada de quitina de langosta]]></article-title>
<source><![CDATA[Revista Iberoamericana de Polímeros]]></source>
<year>2012</year>
<volume>13</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>103-16</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hidalgo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Suárez]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Validación de una técnica potenciométrica para determinar el grado de desacetilación de la quitosana]]></article-title>
<source><![CDATA[Ars Pharm]]></source>
<year>2008</year>
<volume>49</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>245-57</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de la Paz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estabilidad de la quitosana derivada de quitina de langosta Panulirus argus, materia prima]]></article-title>
<source><![CDATA[Ars Pharm]]></source>
<year>2013</year>
<volume>54</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>16-23</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<collab>CECMED</collab>
<source><![CDATA[Centro para el Control Estatal de Medicamentos, Equipos y Dispositivos Médicos. Regulación 41-2007]]></source>
<year>2007</year>
<publisher-loc><![CDATA[Cuba ]]></publisher-loc>
<publisher-name><![CDATA[Validación de métodos analíticos]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="book">
<collab>CECMED</collab>
<source><![CDATA[Centro para el Control Estatal de Medicamentos, Equipos y Dispositivos Médicos. Anexo I-2013]]></source>
<year>2013</year>
<publisher-loc><![CDATA[Cuba ]]></publisher-loc>
<publisher-name><![CDATA[Buenas prácticas para laboratorio de control de medicamentos. Validación de Métodos Analíticos]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="book">
<collab>(USP 41) United States Pharmacopeia</collab>
<source><![CDATA[USP 41-NF 36]]></source>
<year>2018</year>
<publisher-loc><![CDATA[Washington DC ]]></publisher-loc>
<publisher-name><![CDATA[The United States Pharmacopeia Convention SA]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rowe]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
<name>
<surname><![CDATA[Sheskey]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Owen]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chitosan]]></article-title>
<source><![CDATA[Handbook of Pharmaceutical Excipients]]></source>
<year>2009</year>
<page-range>159-61</page-range><publisher-loc><![CDATA[Washington ]]></publisher-loc>
<publisher-name><![CDATA[Pharmaceutical Press and American Pharmacists Association]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sheskey]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Cook]]></surname>
<given-names><![CDATA[WG]]></given-names>
</name>
<name>
<surname><![CDATA[Cable]]></surname>
<given-names><![CDATA[CG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chitosan]]></article-title>
<source><![CDATA[Handbook of Pharmaceutical Excipients]]></source>
<year>2013</year>
<publisher-loc><![CDATA[Washington ]]></publisher-loc>
<publisher-name><![CDATA[Pharmaceutical Press and American Pharmacists Association]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="book">
<collab>EMEA</collab>
<source><![CDATA[European Medicines Agency]]></source>
<year>2003</year>
<publisher-loc><![CDATA[Reino Unido ]]></publisher-loc>
<publisher-name><![CDATA[ICH Topic Q1A (R2) Stability Testing of new Drug Substances and Products]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<collab>CECMED</collab>
<source><![CDATA[Centro para el Control Estatal de Medicamentos, Equipos y Dispositivos Médicos. Regulación No. 23-2000]]></source>
<year>2000</year>
<publisher-loc><![CDATA[Cuba ]]></publisher-loc>
<publisher-name><![CDATA[Requerimientos de los estudios de estabilidad para el registro de productos farmacéuticos nuevos y conocidos]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="book">
<collab>CECMED</collab>
<source><![CDATA[Centro para el Control Estatal de Medicamentos, Equipos y Dispositivos Médicos. Regulación No. 24-2000]]></source>
<year>2000</year>
<publisher-loc><![CDATA[Cuba ]]></publisher-loc>
<publisher-name><![CDATA[Requerimientos de los estudios de estabilidad para el registro de nuevos ingredientes farmacéuticos activos]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de la Paz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estabilidad de las sales de quitosana, obtenidas por secado de aspersión, derivadas de quitina de langosta]]></article-title>
<source><![CDATA[Ars Pharm]]></source>
<year>2015</year>
<volume>56</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>217-24</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="book">
<collab>(EP) European Pharmacopeia</collab>
<source><![CDATA[]]></source>
<year>2017</year>
<edition>9th</edition>
<page-range>1774-2028</page-range><publisher-loc><![CDATA[Strasburg ]]></publisher-loc>
<publisher-name><![CDATA[Council of Europe]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cervera]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Heinämäki]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[de la Paz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Maunu]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of spray drying on physicochemical properties of chitosan acid salts]]></article-title>
<source><![CDATA[AAPS PharmSciTech]]></source>
<year>2011</year>
<volume>12</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>637-49</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Laplante]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Turgeon]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Paquin]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of pH, ionic strength, and composition on emulsion stabilising properties of chitosan in a model system containing whey protein isolate]]></article-title>
<source><![CDATA[Food Hydrocolloids]]></source>
<year>2005</year>
<volume>19</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>721-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de la Paz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[La Rosa]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determinación del balance hidrófilo-lipófilo de la quitosana derivada de quitina de langosta (Panulirus argus) empleando surfactantes no iónicos]]></article-title>
<source><![CDATA[Rev. Cubana de Farmacia]]></source>
<year>2019</year>
<volume>52</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de la Paz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Soler]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estabilidad física de bases emulsionadas e hidrosolubles con quitosana y acetato de quitosana]]></article-title>
<source><![CDATA[J Pharm Pharmacogn Res]]></source>
<year>2017</year>
<volume>5</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>288-300</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ávila]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Costamagna]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Barrientos]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Pucci]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Strumia]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Películas de quitosano con sorbato de potasio unido física y covalentemente Estudios de aplicación]]></article-title>
<source><![CDATA[Revista Iberoamericana de Polímeros]]></source>
<year>2010</year>
<volume>11</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>73-87</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dash]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Murthy]]></surname>
<given-names><![CDATA[PN]]></given-names>
</name>
<name>
<surname><![CDATA[Nath]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chowdhury]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Kinetic modeling on drug release from controlled drug delivery systems]]></article-title>
<source><![CDATA[Acta Pol Pharm]]></source>
<year>2010</year>
<volume>67</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>217-23</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de la Paz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro release of dibucaine hydrochloride from chitosan semisolid vehicles: emulsion and hydrophilic gels]]></article-title>
<source><![CDATA[J Pharm Pharmacogn Res]]></source>
<year>2017</year>
<volume>5</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>96-105</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wallance]]></surname>
<given-names><![CDATA[LG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determination of the Hydrophile-Lipophile Balance of Acacia using various surfactants]]></article-title>
<source><![CDATA[Journal of Pharmaceutical Sciences]]></source>
<year>1961</year>
<volume>50</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>238-9</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de la Paz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[OD]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rapado]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Altanés]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluación viscosimétrica del quitosano derivado de la quitina de langosta]]></article-title>
<source><![CDATA[Revista Iberoamericana de Polímeros]]></source>
<year>2013</year>
<volume>14</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>84-91</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
