<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2304-0106</journal-id>
<journal-title><![CDATA[Anales de la Academia de Ciencias de Cuba]]></journal-title>
<abbrev-journal-title><![CDATA[Anales de la ACC]]></abbrev-journal-title>
<issn>2304-0106</issn>
<publisher>
<publisher-name><![CDATA[Academia de Ciencias de Cuba]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2304-01062021000300030</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evolución epidemiológica y clínica de pacientes con neuropatía óptica epidémica cubana]]></article-title>
<article-title xml:lang="en"><![CDATA[Epidemiological and clinical evolution of patients with Cuban epidemic optic neuropathy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fuentes Pelier]]></surname>
<given-names><![CDATA[Damaris]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santiesteban Freixas]]></surname>
<given-names><![CDATA[Rosaralis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hodelín Tablada]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero García]]></surname>
<given-names><![CDATA[Lázaro Ibrahím]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Docente Dr. Juan Bruno Zayas Alfonso  ]]></institution>
<addr-line><![CDATA[ Santiago de Cuba]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Neurología y Neurocirugía Dr. Rafael Estrada González  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Provincial Clínico Quirúrgico Docente Saturnino Lora  ]]></institution>
<addr-line><![CDATA[ Santiago de Cuba]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Academia de Ciencias de Cuba  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>11</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2304-01062021000300030&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2304-01062021000300030&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2304-01062021000300030&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  En el primer trimestre del año 1992 oftalmólogos de la provincia de Pinar del Río, comenzaron a notificar un número inusual de enfermos con déficit visual bilateral sin manifestaciones llamativas del fondo de ojo, entidad nosológica que se denominó neuropatía óptica epidémica cubana. El objetivo de este trabajo fue describir las características y evolución de los enfermos que fueron afectados por neuropatía óptica epidémica cubana en la provincia Santiago de Cuba, así como identificar la tendencia de la enfermedad.  Métodos:  Se desarrolló una investigación longitudinal desde enero del 2003 hasta diciembre de 2019. La población estuvo constituida por 58 unidades de análisis. Los resultados fueron presentados en forma de tablas de distribución de frecuencias simples y tablas de contingencia.  Resultados:  Las mayores tasas de incidencia con cifras de 0,5 por 100 000 habitantes correspondieron a los años 2009, 2012 y 2015. En el municipio Santiago de Cuba predominó el 84,9 % de sus afectados en áreas urbanas, en Mella esta cifra fue de 77,8 % y en San Luis 80,0 %. El intervalo de 35 a 44 años tuvo el mayor porcentaje para el sexo masculino con 47,2 %, destaca una media aritmética de 39,2, una mediana de 41 y una moda de 37. El 100,0 % de los pacientes aquejaron disminución de la visión. Como conclusión se demostró la existencia de un nuevo periodo de la neuropatía óptica epidémica cubana signado por un patrón endémico con baja incidencia y una tendencia estacionaria.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: In the first quarter of 1992, ophthalmologists from Pinar del Río province began to report an unusual number of patients with bilateral visual deficit without striking manifestations in ocular fundus, an entity that was called the Cuban epidemic optic neuropathy. The objective was to describe the characteristics and evolution of patients who were affected by Cuban epidemic optic neuropathy in the Santiago de Cuba province, as well as to identify the trend of the disease.  Methods: A longitudinal piece of research was carried out from January 2003 to December 2019. The population was composed of 58 analysis units. The results were presented in the form of simple frequency distribution tables and contingency tables.  Results: The highest incidence rates with figures of 0,5 per 100 000 inhabitants correspond to the years 2009, 2012 and 2015. In the municipality of Santiago de Cuba, 84,9 % of those affected occurred in urban areas; in Mella municipality, it was 77,8 % and 80.0 % in San Luis. The interval from 35 to 44 years had the highest percentage for males, 47,2 %; an arithmetic mean of 39,2, a median of 41 and a mode of 37 stand out. 100 % of the patients suffered a decrease in their vision. Conclusion: the existence of a new period of Cuban epidemic optic neuropathy was demonstrated, marked by an epidemic pattern with low incidence and a stationary trend.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[epidemia]]></kwd>
<kwd lng="es"><![CDATA[fondo de ojo]]></kwd>
<kwd lng="es"><![CDATA[neuritis óptica]]></kwd>
<kwd lng="es"><![CDATA[neuropatía óptica epidémica cubana]]></kwd>
<kwd lng="es"><![CDATA[patrón endémico]]></kwd>
<kwd lng="en"><![CDATA[epidemic]]></kwd>
<kwd lng="en"><![CDATA[ocular fundus]]></kwd>
<kwd lng="en"><![CDATA[optic neuritis]]></kwd>
<kwd lng="en"><![CDATA[Cuban epidemic optic neuropathy]]></kwd>
<kwd lng="en"><![CDATA[endemic pattern]]></kwd>
</kwd-group>
</article-meta>
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