<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272020000400569</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Carcinoma basocelular de alto riesgo, respuesta al tratamiento combinado con HeberFeron y radioterapia superficial. Presentación de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[High risk basal cell carcinoma, response to combined HeberFeron treatment and surface radiotherapy. Presentation of a case]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Fleites]]></surname>
<given-names><![CDATA[Damarys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Betancourt Pérez]]></surname>
<given-names><![CDATA[Amelia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín Pozo]]></surname>
<given-names><![CDATA[Yordan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico Quirúrgico Universitario &#8220;Arnaldo Milián Castro&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>14</volume>
<numero>4</numero>
<fpage>569</fpage>
<lpage>575</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272020000400569&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272020000400569&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272020000400569&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  el carcinoma basocelular es un tumor maligno de localización cutánea y es el más frecuente en humanos, especialmente en la raza blanca. Cuando aparece en la región periocular se considera de alto riesgo por la posibilidad de invasión a estructuras adyacentes y subyacentes.  Información del paciente:  paciente masculino, fototipo cutáneo II, que acudió a consulta por la presencia de una lesión tumoral de 5X2,5cm de diámetro, localizada en la sien izquierda, que involucraba el ángulo externo del ojo. Se realizaron los diagnósticos clínico e histológico y se decidió tratamiento con HeberFeron debido a la localización y al tamaño de la lesión. Se realizó un primer ciclo de tratamiento y se obtuvo una respuesta parcial con una reducción de la lesión a 2x2cm, y se decidió un segundo ciclo de tratamiento. Se mantuvo como enfermedad estable, por lo que se indicó tratamiento con radioterapia superficial; presentó respuesta completa de la enfermedad, clínica y dermatoscopia.  Conclusión:  la terapia con HeberFeron fue efectiva para la reducción de la lesión y, combinada con radioterapia superficial, logró una respuesta clínica completa y excelentes resultados estéticos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  basal cell carcinoma is a malignant tumor of cutaneous location and is the most frequent in humans, especially in the white race. When it appears in the periocular region it is considered to be of high risk due to the possibility of invasion into adjacent and underlying structures.  Case report:  male patient, skin phototype II, who came to the clinic because of the presence of a tumor lesion of 5X2.5cm in diameter, located in the left temple, involving the external angle of the eye. Clinical and histological diagnosis was made and treatment with HeberFeron was decided due to the location and size of the lesion. A first cycle of treatment was performed and a partial response was obtained with a reduction of the lesion to 2x2cm, and then a second cycle of treatment was decided. It was maintained as a stable disease, so treatment with superficial radiotherapy was indicated; it presented complete disease response, clinical and dermatoscopic.  Conclusions:  HeberFeron therapy was effective in reducing the lesion and, combined with superficial radiotherapy, achieved a complete clinical response and excellent aesthetic results.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[carcinoma basocelular]]></kwd>
<kwd lng="es"><![CDATA[HeberFeron]]></kwd>
<kwd lng="es"><![CDATA[radioterapia superficial]]></kwd>
<kwd lng="es"><![CDATA[tratamiento combinado]]></kwd>
<kwd lng="en"><![CDATA[basal cell carcinoma]]></kwd>
<kwd lng="en"><![CDATA[HeberFeron]]></kwd>
<kwd lng="en"><![CDATA[surface radiotherapy]]></kwd>
<kwd lng="en"><![CDATA[combined treatment]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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