<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272021000400497</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estudio de la supervivencia al año de pacientes con metastásis de cáncer de origen desconocido]]></article-title>
<article-title xml:lang="en"><![CDATA[Survival study at one year of patients with metastatic cancer of unknown origin]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosell Díaz]]></surname>
<given-names><![CDATA[Marisel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Hernández]]></surname>
<given-names><![CDATA[Dianelí Lorely]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Negrín]]></surname>
<given-names><![CDATA[Halbert]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez Domínguez]]></surname>
<given-names><![CDATA[Lázaro José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Clínico Quirúrgico Universitario &#8220;Arnaldo Milián Castro&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>15</volume>
<numero>4</numero>
<fpage>497</fpage>
<lpage>510</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272021000400497&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272021000400497&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272021000400497&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  el pronóstico de los pacientes con metastásis de cáncer de origen desconocido es precario, solo el 25% de los pacientes están vivos al año.  Objetivo:  determinar la influencia del diagnóstico histopatológico en la supervivencia al año de pacientes con metástasis de cáncer de origen desconocido.  Métodos:  se realizó un estudio observacional de cohorte con los pacientes que ingresaron en el Hospital &#8220;Arnaldo Milián Castro&#8221; en el período comprendido entre enero de 2011 y diciembre de 2017.  Resultados:  fueron estudiados 57 pacientes, 10 resultaron vivos y 47 fallecidos. La hipertensión arterial (47,4%) y el tabaquismo (45,6%) fueron los antecedentes patológicos personales más frecuentes. La astenia, la anorexia y la pérdida de peso, entre otras, fueron las manifestaciones clínicas al ingreso más significativamente asociadas a la mortalidad. En el grupo de los pacientes fallecidos los valores medios de la hemoglobina, la albúmina sérica y los triglicéridos fueron significativamente menores, mientras que el lactato deshidrogenasa fue mayor. Los pacientes con tumor primario desconocido no sobrevivieron al año y aproximadamente el 20% sobrevive a los seis meses, los que tuvieron diagnóstico de adenocarcinoma poco diferenciado aproximadamente en un 10% sobrevivieron a los 11 meses y los pacientes con primario de pulmón sobrevivieron aproximadamente un 10% al año. Tener tumor primario desconocido aumentó el riesgo de morir aproximadamente 3,6 veces, adenocarcinoma poco diferenciado 2,0 veces y el tumor primario de pulmón 1,9.  Conclusiones:  el diagnóstico histopatológico de tumor primario, adenocarcinoma poco diferenciado y el tumor primario de pulmón influyen en la mortalidad del paciente con metástasis de cáncer de origen desconocido.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  the prognosis of patients with metastatic cancer of unknown origin is precarious, only 25% of patients are alive at one year.  Objective:  to determine the influence of histopathological diagnosis on one-year survival in patients with cancer metastases of unknown origin.  Methods:  an observational cohort study was conducted with patients admitted to the "Arnaldo Milián Castro" Hospital in the period from January 2011 to December 2017.  Results:  57 patients were studied, 10 were alive and 47 died. Arterial hypertension (47.4%) and smoking (45.6%) were the most frequent personal pathologic antecedents. Asthenia, anorexia and weight loss, among others, were the clinical manifestations at admission most significantly associated with mortality. In the group of deceased patients the mean values of hemoglobin, serum albumin and triglycerides were significantly lower, while lactate dehydrogenase was higher. Patients with unknown primary tumor did not survive to one year and approximately 20% survive to six months, those with a diagnosis of poorly differentiated adenocarcinoma approximately 10% survived to 11 months and patients with lung primary survived approximately 10% to one year. Having unknown primary tumor increased the risk of dying approximately 3.6-fold, poorly differentiated adenocarcinoma 2.0-fold and primary lung tumor 1.9-fold.  Conclusions:  histopathological diagnosis of primary tumor, poorly differentiated adenocarcinoma and primary lung tumor influence mortality in patients with metastases of cancer of unknown origin.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[cáncer de origen desconocido]]></kwd>
<kwd lng="es"><![CDATA[supervivencia]]></kwd>
<kwd lng="es"><![CDATA[metástasis]]></kwd>
<kwd lng="en"><![CDATA[cancer of unknown origin]]></kwd>
<kwd lng="en"><![CDATA[survival]]></kwd>
<kwd lng="en"><![CDATA[metastasis]]></kwd>
</kwd-group>
</article-meta>
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