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3. Devereaux PJ, Yang H, Guyatt GH, Leslie K, Villar JC, Monteri VM, et al. Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery. Am Heart J. 2006;152:223-30.