Abstract

GONZALEZ CORTINAS, Modesto. Patogenia de las espondiloartropatías seronegativas. Rev cubana med [online]. 1998, vol.37, n.1, pp. 28-35. ISSN 1561-302X.

The function of HLA-B27 in the pathogenesis of seronegative spondyloarthropathies was studied. The zone of union of the peptides of the molecule known as «big pocket 45» was described in detail. The molecular mimicry between arthritogenic bacteria and HLA-B27, the positivity of HLA-B27 and the persistance of enterobacterial infections, the HLA-B27 modifying factors, and the model of arthritogenic peptide were discussed as present hypotheses connected with the appearance of the disease. The function of the CDB-positive T-cell in the outbreak of the disease, as well as its control by the CD4-positive T-lymphocytes was explained.

Keywords : SPONDILITIS, ANKYLOSING [etiology]; SPONDYLITIS, ANKYLOSING [immunology]; HLA-B27 ANTIGEN [genetics]; HLA-B27 ANTIGEN [immunology]; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GENES, MHC CLASS I.

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