Abstract

BORROTO DIAZ, Gerardo et al. Correlation between the tubulointerstitial and vascular damage in lupus nephritis with some clinical variables. Rev cubana med [online]. 2006, vol.45, n.1, pp. 0-0. ISSN 1561-302X.

Tubulointerstitial and vascular lesions are frequent in lupus nephritis, in spite of the fact that they are not included in the WHO classification of 1995. 339 renal biopsies were reviewed in order to correlate certain clinical variables with the tubulointerstitial and vascular lesions and to know their frequency. It was determined the frequency of the tubulointerstitial (101/29.8 %) and vascular damage (65/19.2). The incidence of tubulointerstitial lesions in different types of lupus glomerulonephritis was also taken into account: 0 in type I, 7/9.8 % in type II, 8/15.7 % in type III, 65/50 % in type IV, 2/6.3 % in type V, and 16/100 % in type VI. It was proved that the tubulointerstitial and vascular damage was the expression of clinical severity, since it was accompanied with a higher frequency of hypertension (83/82 % and 64/97 %) than when the lesions were not present (128/58 %), a longer time of evolution of the disease (3.4, 2.8 and 1.82 years) and figures of pancreatic creatinine of 189.1, 172.1 and 134.5 mmol/L for tubulointerstitial lesions, vascular lesions and in the absence of them, respectively. Proteinuria was higher in tubulointerstitial lesions (3.4 g/L) and lower in patients with vascular lesions (1.89). The contrary occurs with the hematuria incidence (65/100 % for vascular lesions and 48/47.5 % tubulointerstitial lesions). In patients with no lesions in these structures the results were: 2.02 g/L for proteinuria and 143/61 % for hematuria.

Keywords : Lupus nephritis; tubulointerstitial; blood vessels; hypertension; hematuria; proteinuria; evolution time and creatinine.