Abstract

HERNANDEZ CRUZ, Calixto et al. Tratamiento con quimioterapia de la leucemia mieloide aguda en el Hospital “Hermanos Ameijeiras.” Experiencia de 20 años de trabajo. Rev cubana med [online]. 2006, vol.45, n.1, pp. 0-0. ISSN 1561-302X.

Acute myeloid leukaemia (AML) represents 80% of the total number of acute leukemia affecting human beings and its prognosis remains very unfavourable. This paper was aimed at showing the experience accrued by the hospital in the presentation and treatment of this disease with the use of chemotherapy. The results achieved in the treatment of 193 cases diagnosed with AML and treated at the Hematology Service for 20 years were analyzed. Average age of patients was 42.7 years and the most frequent FAB subtype was M2. Non M3 AML cases showed a complete remission index of 45.5% for all the age groups and of 60.4% for under 60 year-olds. The global survival rate was 8.9% after 5 years of follow-up for patients under 60 years, without survivors for the same length of time in the over 60 years-old group. Complication-free survival was 16.2% in general at 5 years of follow-up. The patients with M3 AML had a complete remission index of 75%.  Global survival and complication-free survival at 5 years were 40.4% and 62.2% respectively. The 67.7% of cases died from a disease resistant to treatment or from a relapse.

Keywords : Acute myeloid leukaemia; complete remission; global survival rate; complication-free survival rate.