Abstract

PINOL JIMENEZ, Felipe et al. Histomorphological colon lesions in patients with elevated total biliary acids in feces. Rev cubana med [online]. 2006, vol.45, n.2, pp. 0-0. ISSN 1561-302X.

The increase of the concentration of total biliary acids in the intestinal light, specially the secondary, due to metabolism disorders, provokes damages at the mucosa level of the whole digestive tract. This confirms its cytotoxic effect on the colon mucosa. The association between the increase of the elevated levels of total and secondary biliary acids and the appearance of inflammation of the colon mucosa, polyps and colorectal cancer is internationally reported. An exploratory study was conducted to determine the presence of hystomorphological colon lesions in patients with elevated levels of biliary acids in feces. It was found that 54 patients presented histomorphological lesions in some of the anatomical segments of the colon. The polyps were the most frequent endoscopically diagnosed lesions, and they were generally localized in the rectosigmoid region. All the patients had unspecific colitis of mild and moderate intensity in some segment of the colon. The most commonly diagnosed polyps were the neoplastic adenomatous polyps, and most of them presented moderate dysplasia. Mild dysplasia was only observed in the tubular adenomas. It was concluded that in those patients with a disorder of the acid biliary metabolism, its determination in feces may serve as a screening test of premalignant or malignant lesions.

Keywords : Total biliary acids in feces; vesicular lithiasis; patients undergoing cholecystectomy.