Abstract

VALDES GARCIA, Suria; DEL BARRIO ALONSO, Gloria; GUTIERREZ GAITEN, Yamilet  and  MORIER DIAZ, Luis. Evaluación preliminar de la actividad antiviral del extracto acuoso de Phyllanthus orbicularis frente al virus VHS-1. Rev Cubana Med Trop [online]. 2003, vol.55, n.3, pp. 169-173. ISSN 1561-3054.

The antiviral activity of the aqueous extract of Phyllanthus orbicularis, a member of the Euohorbiacea family, against the simple herpes virus type1 was evaluated in cellular culture, specifically in fibroblasts of human prepucium, and in an animal model, Balb-c mice. The extracelullar effect of the extract on HIV-1 proved to be effective. A selective index of 44 was obtained, which shows a possible virucidal action on the particle. In the trial in vivo, the topical administration of the aqueous extract (12 mg/kg) reduced significantly the development of lesions in mice subcutaneously infected with HIV-1 (1 x 106 UFP). These results suggest the consideration of Phyllanthus orbicularis as a possible anti-HIV-1 candidate

Keywords : PLANTS, MEDICINAL; CLINICAL TRIALS [method]; HERPES VIRUS, HUMAN; ANTIVIRAL AGENTS.

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