Abstract

GUERREIRO HERNANDEZ, Ana María et al. Longitudinal study of antineutrophil cytoplasmic antibodies in patients with sickle cell anemia. Rev Cubana Hematol Inmunol Hemoter [online]. 2000, vol.16, n.2, pp. 122-124. ISSN 1561-2996.

A longitudinal study was made to detect antineutrophil cytoplasmic antibodies (ANCA) in 13 patients with sickle cell anemia in vasocclusive crisis and basal state by using an indirect immunofluorescence method. Of 34 serum samples, 16 were in vasocclusive crisis and 12 of them corresponding to 10 patients revealed the presence of p-ANCA. Neither p-ANCA nor c-ANCA was observed in the rest of the samples taken in vasoclussive crisis and in basal state. The results achieved signaled a possible involvement of p-ANCA in ischemic damage as well as the importance of their measurement in the diagnosis of vasocclusive crisis in patients with sickle cell anemia

Keywords : ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANEMIA, SICKLE CELL; HEMATOLOGIC DISEASES.

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