Abstract

RAMOS ROBLEDO, Alejandro  and  DEL BUSTO MESA, Abdel. Presentation of a case of agranulocytosis caused by propylthiouracil. Rev Cubana Invest Bioméd [online]. 2020, vol.39, n.2  Epub June 01, 2020. ISSN 1561-3011.

A female 33-year-old patient with an 8-year history of diffuse thyroid goiter presents at the emergency service with shortness of breath, a 39-40ºC fever, a sore throat and palpitation of 3 days' evolution. Physical examination revealed exophthalmos, hypopigmented mucosas, a purulent pharynx dotted with whitish spots, arthralgia and tachycardia. Complementary tests found anemia, leukopenia and pancytopenia upon consumption of propylthiouracil (50 mg) for a long period. The diagnosis is agranulocytosis resulting from an adverse reaction to propylthiouracil. After being treated the patient recovered from her severe status with the use of granulocyte colony stimulating factors.

Keywords : agranulocytosis; hyperthyroidism; thyroid goiter.

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