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Revista Cubana de Investigaciones Biomédicas
On-line version ISSN 1561-3011
Abstract
VELAZQUEZ DOMINGUEZ, José Antonio and MORALES ESPINDOLA, Rubi Ixchell. Synergic effect of a biphosphonate with vitamin D. Rev Cubana Invest Bioméd [online]. 2021, vol.40, n.1 Epub Apr 01, 2021. ISSN 1561-3011.
Introduction:
Biphosphonates are considered to be a group of very useful drugs used to treat osseous tissue conditions, since they foster resorption. They are first line in the treatment of osteoporosis, Paget's disease, multiple myeloma and malignant hypercalcemia. Vitamin D, on the other hand, is an essential nutrient whose main function is calcium (Ca+2) and phosphate (P4 3-) homeostasis.
Objective:
Describe the molecular and pharmacological aspects of the action of a biphosphonate (alendronate sodium) and vitamin D on osseous diseases.
Methods:
A selection was made of the most updated references about relevant aspects of alendronate and vitamin D. The databases consulted were Pubmed, Uniprot and Protein Databank.
Conclusions:
The synergy between alendronate and vitamin D generates beneficial effects on osseous tissue. However, their use should be controlled, since side-effects may affect other tissues.
Keywords : bisphosphonates; alendronate; cholecalciferol; osteoporosis.