Abstract

PEDROSO FLAQUET, Plácido  and  DIAZ GONZALEZ, Manuel. Comportamiento reactogénico de la vacuna cubana contra la hepatitis B en niños física y mentalmente discapacitados. Rev Cubana Med Gen Integr [online]. 2000, vol.16, n.5, pp. 423-429. ISSN 1561-3038.

The reactogenecity of the Cuban recombinant yeast-derived hepatitis B vaccine (Heberbiovac-HB) was studied on administering doses of 5 and 10 mg and using the immunization scheme 0 in 2 groups of physical and mentally disabled children aged 5-14. The second dose was given at a month and the third one at 6 months. The symptoms observed in the whole population under study were 5,1 %, whereas in the groups vaccinated with 5 and 10 mg, the symptomatology was 4,8 and 5,4 %, respectively. No significant differences were observed in the postvaccinal symptoms between the studied groups. The predominant sign was low-grade fever with 84,9 % of the positive observations found. In our study, it was confirmed the low reactogenecity of the Heberbiovac-HB vaccine, which makes it safe and recommendable for the protection against the hepatitis B virus in the groups of physical and mentally disabled children that were studied

Keywords : HEPATITIS B VIRUS; VACCINES, SYNTHETIC [administration & dosage]; DISABLED CHILDREN.

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