Abstract

RODRIGUEZ AURRECOCHEA, Juan Carlos et al. Evaluación de la toxicidad por administración única del producto QT2B21 en ratas Sprague Dawley. Rev Cubana Plant Med [online]. 2004, vol.9, n.1, pp. 0-0. ISSN 1028-4796.

A study of acute toxicity was conducted in Sprague Dawley rats of both sexes by the sole oral administration of the QT2B21 product obtained from the species of Nephrolepis cordifolia fern to determine its toxicity. 3 dose levels were evaluated: 33.33, 133.32, and 533.28 mg/Kg. Some hematologic indexes were determined without finding toxic effects attributable to the administration of the product. The anatomopathological (by macroscopic examination) and histopathological studies of the main organs were conducted. Their examination did not show macroscopic alterations. According to the result of the histopathological study, only statistically significant differences were observed in the percentage of relative weight of the testes in the group treated with the intermediate dose as regards the control group. This effect did not depend on the dose. It was concluded that the sole oral administration of the QT2B21 product did not bring about alterations due to toxicity that may be attributed to it. This product was considered as tolerable in Sprague Dawley rats of both sexes in the dose range from 33.33 to 533.28 mg/Kg of weight.

Keywords : PLANTS, MEDICINAL [toxicity]; PLANT EXTRACTS [toxicity]; RATS, SPRAGUE-DAWLEY; DISEASE MODELS, ANIMAL.