Abstract

PEREZ OJEDA, Yoan; JIMENEZ LOPEZ, Mildrey  and  BENITEZ PEREZ, María Obdulia. Negative viral load in persistent positive SARS-CoV-2 patients and use of convalescent plasma. Medicentro Electrónica [online]. 2023, vol.27, n.3  Epub Sep 01, 2023. ISSN 1029-3043.

There is no specific medication against SARS-CoV-2 and the treatment consists mainly of supportive measures. Convalescent plasma transfusion consists of passively administered polyclonal antibodies, which generate an immediate immune response and decrease viral load. The objective of the study was to describe hospital stay and real-time polymerase chain reaction negativization in persistently positive patients with the use of convalescent plasma. A prospective, cross-sectional and descriptive study was carried out in 8 persistently positive patients who received such plasma at "Cmdte. Manuel Fajardo" Clinical and Surgical University Hospital from September to November 2020. The highest percentage of cases required a dose of convalescent plasma to make the RT-PCR negative. The most frequent hospital stay was from 14 to 19 days; 62.50% of the patients had a negative evolutionary RT-PCR, 24 hours after administering the last dose of this plasma.

Keywords : COVID-19 serotherapy; SARS-CoV-2; polymerase chain reaction.

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