Abstract

RUIZ REYES, Roberto E; CRESPO CERVANTES, Liuba  and  TEJEDA CABRERA, Yaniset. Chemoprophylaxis in the vesical tumoral recurrence. Rev. Med. Electrón. [online]. 2012, vol.34, n.4, pp. 439-449. ISSN 1684-1824.

The superficial bladder tumors are characterized by a high rate of recurrence taking place especially within the first two years that is even higher in the high risk groups. There is an agreement in the usefulness of the Calmette-Guerin Bacillus (CGB) to diminish the tumoral recurrence. The intravesical chemotherapy with other medications have demonstrated its profit or not in decreasing the recurrence of these bladder tumors. Between 1999 and 2008 we studied and treated 110 patients (96 men and 14 women), aged in average 63 years old. They were divided into three groups for the treatment of the tumoral recidivism after the transurethral resection or partial cystectomy, using three different chemoprophylactic agents and inmunomodulators (Thio-Tepa, BCG+Transference Factor, Doxorubicin +Interferon Alpha 2b). The objective of this research was presenting our experience in the treatment of these patients during five years, obtaining better results in the group treated with doxorubicin + interferon alpha 2b, followed by the group treated by means of BCG + transference factor, with a remarked decrease of the recurrence and a limitation in the long term progression of the disease.

Keywords : BCG; factor de transferencia; chemoprophylaxis; vesical tumoral recidivism; thio-tepa; BCG; transference factor; doxorubicin; interferon alpha 2b.

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