Abstract

PEREZ MEJIAS, Adina; BARBER FOX, María Ofelia  and  PEREZ RAMOS, Aydelín. Glomerular-tubular imbalance in the pathophysiology of the arterial hypertension associated with low birth weight . Rev haban cienc méd [online]. 2011, vol.10, n.2, pp. 0-0. ISSN 1729-519X.

High blood pressure (hypertension) is a global health problem. Pathophysiologic mechanisms are unclear in their appearance. Reports have linked low birth weight and intrauterine growth retardation with hypertension in adulthood, related to incomplete nephrogenesis. The development of hypertension in rats leading to proximal tubular hypertrophy indicates that the imbalance between glomerular and tubular functions generates excretory kidney failure and it could be in renal damage of the low weight. In order to assess the possible involvement of glomerular-tubular imbalance with tubular preponderance, within pathophysiological renal mechanisms described in hypertension associated with intrauterine growth retardation, theoretical methods were used. The theoretical framework developed was based on data accessed in scientific journals. We conclude that the state of glomerular-tubular imbalance with tubular preponderance has been little studied in relation to the development of hypertension in these subjects. This phenomenon is not recognized, so far as «abnormal» renal, which may be a primary hypertensogenous mechanism.

Keywords : Glomerulo-tubular imbalance; low birth weight; intrauterine growth retardation; arterial hypertension; kidney; renal pathophysiology of hypertension.

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