Abstract

GONZALEZ-COSTA, Maricarmen  and  PADRON GONZALEZ, Alexander Ariel. Melatonin and its role in inflammatory processes. Rev Cuba Reumatol [online]. 2019, vol.21, n.2  Epub Aug 01, 2019. ISSN 1817-5996.

Melatonin is a pleiotropic neuroendocrine hormone, produced mainly by the pineal gland that regulates the circadian rhythm, is anti-inflammatory, immunomodulatory, neuroprotective, antioxidant. A review on the subject was performed using articles of free access in the Pubmed database from January 2013 to September 2018 with the aim of describing the role of this biomolecule in some autoimmune and rheumatological diseases, as well as in other acute and chronic inflammatory processes. Melatonin has shown favorable actions when it is administered in diseases such as multiple sclerosis, diabetes mellitus type I, cancer. However, it can worsen crises in rheumatoid arthritis.

Keywords : melatonin; inflammation; autoimmune diseases; rheumatological diseases.

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