Abstract

MARTINEZ GONZALEZ, Larisa; LEON VAZQUEZ, Alfonso R  and  ORIZONDO PAJON, Sergio A. Clonidina intratecal para alivio del dolor posoperatorio en cirugía proctológica: Su combinación con otros agentes. Rev Cubana Cir [online]. 2001, vol.40, n.4, pp. 297-304. ISSN 1561-2945.

A clinicotherapeutic comparative and prospective randomised blind study was conducted to evaluate the efficacy of clonidine of national production administered by intrathecal route in combination with other agents to relieve postoperative pain (PP) and to describe the adverse effects attributable to its use. 100 patients that were scheduled to undergo proctological surgery were selected and divided into 4 groups of 25 cases each: hyperbaric lidocaine hydrochloride (G-1), hyperbaric lidocaine hydrochoride plus fentanyl (G-2), hyperbaric lidocaine hydrochloride plus clonidine (G-3), and hyperbaric lidocaine hydrochloride plus fentanyl plus clonidine (G-4). The longest analgesia time (AT) was attained in G-4 and no patient had acute pain in this group. The lowest analgesia time was found in G-1 , as well as the highest number of patients with acute pain. Transoperative hypotension and postoperative retention of urine were the commonest adverse effects, although they were not significant.

Keywords : CLONIDINE [therapeutic use]; INJECTIONS, SPINAL [therapeutic use]; PAIN, POSTOPERATIVE [drug therapy]; DRUG THERAPY, COMBINATION; POSTOPERATIVE CARE; RECTAL DISEASES [surgery].

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