Abstract

FITERRE LANCIS, Irene et al. Factors associated with an inappropriate use of cephalosporins in admitted patients. Rev Cubana Cir [online]. 2010, vol.49, n.3, pp. 0-0. ISSN 1561-2945.

INTRODUCTION. The cephalosporins become a valuable therapeutical resort but its inappropriate use has been associated with the development of antimicrobial resistance a very significant problem in the daily clinical practice. There are available reports on this subject in the Cuban medical literature, thus a study was made to identify the frequency and the factors associated with the inappropriate use of cephalosporins in admitted patients. METHODS. A descriptive study was conducted using the serial detailed prevalences of cephalosporins prescriptions in patients admitted in "Joaquín Albarrán" Hospital (from May, 2008 to April, 2009). From patients we get the general features and of the cephalosporin prescription and this information was analyzed by experts to identify the cases of inappropriate prescription. Using the logistic regression it was determined the unsuitable association degree with the independent variables. A discriminant analysis was carried out to identify the variables to differentiate the patient groups to determine the prescription quality. RESULTS. There was inadequacy in the 18,4% of the 711 assessed patients ant these were higher in younger patients (p < 0,001), non-respiratory localization of infection (p < 0,001), of surgical service (p < 0,001), a history of recent surgery (p < 0,005) and chronic renal failure (< 0.05). The history of chronic respiratory failure was associated with a suitable prescription (p < 0,05). The above variables discriminate the patient groups to adapt the prescription. CONCLUSION. Inadequacy frequency is identified defining as factors related to age, the infection non-respiratory localization, the chronic renal failure background, the recent surgery and being served in surgical services.

Keywords : Cephalosporins; inadequacy; hospital; Cuba.

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