Abstract

MORALES NAVARRO, Denia. Tissue engineering as a pillar of regenerative medicine in dentistry. Rev Cubana Estomatol [online]. 2014, vol.51, n.3, pp. 288-304. ISSN 0034-7507.

Introduction: the wish to create more biological alternatives for the permanent implantation of synthetic materials has fostered the development of tissue engineering. As one of the pillars of regenerative medicine, tissue engineering broadens the range of research and clinical application possibilities in dentistry. Objective: carry out a bibliographic review about tissue engineering as a pillar of regenerative medicine in dentistry. Methods: the review covered the period May-June 2013. An evaluation was conducted of high impact journals from the Web of Sciences (43 journals) and 2 Cuban journals. Databases from reference systems, such as MEDLINE, PubMed and Scielo, were consulted with the aid of search terms like "tissue engineering AND dentistry", "regenerative medicine", "biomaterials", " scaffolds", "nanotechnology", and their Spanish counterparts. The review included papers in English and Spanish, and publications from the last five years. Of the 127 papers obtained, the reviewers selected the 55 which approached the study topic in a more comprehensive manner. One book was reviewed. Results: an analysis of the representativeness of papers in the scientific journals where they were published showed that 5.45 % corresponded to the International Journal of Nanomedicine and Biomater. The remaining papers were evenly distributed among the other journals. Conclusions: many are the publications dealing with the subject of tissue engineering in biomedicine and particularly in dentistry. In general terms, all of them agree that research into stem cells biology and modern biomaterials has created interesting opportunities for regeneration and therapy based on tissue engineering. Appropriate management of the elements making up tissue engineering, alongside the tissue signaling system, nanomaterials, management systems, stem cells and biomaterials, broaden the possibilities of application in contemporary and future dentistry.

Keywords : tissue engineering; dentistry; biomaterials; scaffolds; nanotechnology; bioactive substances.

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