Abstract

CASTINEIRAS DIAZ, Mirta; CAIRO OJEDA, Alicia; PERDOMO LOPEZ, Ileana  and  PERDOMO NARANJO, Urbano. Preformulación de vitamina A en tabletas. Rev Cubana Farm [online]. 1996, vol.30, n.1, pp. 0-0. ISSN 1561-2988.

Several studies were carried out about the possible influence of some components in the degradation of vitamin A acetate. There was a selection of components that could make possible the future design of this product formulations for its production by direct compression; among them there are microcristalline cellulose ph 101, mannitol, sucrose, lactose, cornstarch, dehydrated calcium phosphate, talc, magnesium stearate, and silica. Some components, as lactose and talc, were confirmed as accelerators for vitamin A degradation when coexisting in the tablets formulation. According to the results achieved, 4 formulations designed fulfilled all the technological parameters, and there were formulations obtained that kept their valuation between 90 and 110 % (this is the USP XXII established range) after a year from its manufacturing, which was coincident with the period of life issued by the manufacturer.

Keywords : PHARMACEUTICAL AIDS; CHEMISTRY, PHARMACEUTICAL; VITAMIN A..