Abstract

RODRIGUEZ CHANFRAU, Jorge E  and  ROIG GUTIERREZ, Bárbara. Determinación de primidona por valoración potenciométrica en suspensión oral de primidona. Rev Cubana Farm [online]. 1996, vol.30, n.2, pp. 0-0. ISSN 1561-2988.

Primidone oral suspension is used as an antiepileptic and anticonvulsive. The quantitative determination of primidone oral suspension may be carried out, according to the literature review, by the gaseous chromatography method and by the Kejldhal method. The results are reproducible and accurate in both; however, the first requires an expensive equipment, which is not always available in our small laboratories, and the second one is long and laborious. Therefore, it was developed a simpler and less laborious method able to quantify the amount os primidone in the suspension and to meet the industry's requirements. To this end, it was created a method of potentiometric residual assessment, and a basic hydrolisis with sodium hydroxide 0.5 mol/L was previously carried out. The factibility of the method proposed was checked and it proved to be specific, precise and exact. The analytical results were compared with those obtained by the methods reported in literature. A statistical study was conducted and the equivalence between both methods was demonstrated.

Keywords : PRIMIDONE [analysis]; ADMINISTRATION ORAL; CHROMATOGRAPHY GAS; POTENTIOMETRY [methods].