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Revista Cubana de Farmacia
On-line version ISSN 1561-2988
Abstract
ALFONSO VALDES, Yalile; RIBAS AVILA, María del Carmen; BALLENILLA RODRIGUEZ, Thais and GUERRA SARDINAS, Isabel María. Clonazepan: Estudio preclínico de una formulación nacional. Rev Cubana Farm [online]. 1996, vol.30, n.2, pp. 0-0. ISSN 1561-2988.
A comparative study of 2 clonazepam formulations, the national formulation in tablets 1 mg, batch 2 003, and the RivotrilR 0.5 mg imported from La Roche, batch 818 997, Spain, was carried out. Their anticonvulsant activity was evaluated by inducing convulsions with pentylenetetrazole; whereas the motor coordination and the myorelaxing effect were evaluated by using the rotatory rod method in Swiss albinic mice from the Biological Control Lab colony, in both cases. The two products were active to convulsions, but the national one was stronger than the imported one. No significant difference was observed in the other two parameters. Of the formulations studied a higher therapeutic margin was obtained with the national product.
Keywords : CHEMISTRY; PHARMACEUTICAL; CLONAZEPAM [chemistry]; CARBOXYMETHRYLCELLULOSE [administration & dosage]; MICE.