Abstract

ROJAS MARTINEZ, Roberto; PEREZ CABRERA, Adalberto; ROJAS DEL CALVO, Adriana M  and  RODRIGUEZ SOSA, Víctor. Dosis letales de sulfato de quinina y de quinindina en el ratón: Influencia del sexo. Rev Cubana Farm [online]. 1996, vol.30, n.2, pp. 0-0. ISSN 1561-2988.

The influence of sex on the quinine sulphate and quinidine lethality in mice was studied by two expiermental series: dose calculation according to Litchfield and Wilcoxon's methods, and observation of mortality produced by the administration of a unique prefixed dose of each drug. The results of the first series were processed as it is described in the above mentioned method (limits, lineality, parallelism, and relative potency). In the second series, it was used the Fisher's exact probability test. Similar lethal doses values were obtained with both drugs in connection with sex, but a significant differences was found between males and females. It was concluded that the female mouse was much more sensitive to the lethal effect of the drugs studied. Some factors that may influence on the effective doses values of these drugs are analyzed.

Keywords : QUINIDINE [analoss & derivatives]; QUININE [analoses & derivatives]; LETHAL DOSE 50; MICE.