Abstract

MARTINEZ ALVAREZ, Luis; FERNANDEZ SIERRA, Rolando  and  GUTIERREZ, Yacqueline. Determinación de un polimorfo de la cimetidina mediante la calorimetría diferencial de barrido. Rev Cubana Farm [online]. 1997, vol.31, n.3, pp. 171-176. ISSN 1561-2988.

The difference between two substances of similar mollecular mass but of different internal structuras -cimetidine A and B- was established by using the differential scanning calorimetry. It was proved that only one of them, cimetidine B, has the required pharmacological activity, which means that it fulfills the pharmacopoeia specifications.

Keywords : CALORIMETRY, DIFFERENTIAL SCANNING [methods]; CIMETIDINE [chemistry]; CHEMISTRY, PHARMACEUTICAL.