Abstract

LICEA TORNES, María Victoria  and  MARTINEZ DE SANTELICES CUERVO, Marcía. Racionalización de la técnica para la determinación de la concentración de lidocaína al 2 %. Rev Cubana Farm [online]. 1997, vol.31, n.3, pp. 171-176. ISSN 1561-2988.

The lidocaine chlorhydrate is a local anesthestic that may be used by endovenous or subcutaneous route, depending of its form of presentation, with or without preserve. The concentration of lidocaine chlorhydrate in the injection is determined by an anhydrovolumetric method that requires a considerable use of imported reactive. Preliminary assays were made in which the volumen of extraction as well as the number of extractions were varied in order to rationalize this technique. The best results were obtained with 10 mL of chloroform in 3 extractions, which allowed the saving of 70 % of this solvent.

Keywords : LIDOCAINE [analysis]; CHEMISTRY, PHARMACEUTICAL [methods]; DRUG DESING; INJECTIONS.